MAGOH and CEP70

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGOH	CEP70
Description		mago homolog, exon junction complex subunit	centrosomal protein 70
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14	Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton
	Molecular Function	RNA Binding Protein Binding	Protein Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus Regulation Of Translation RNA Splicing Regulation Of MRNA Processing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Femur bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 28196072)
Interacting Genes		22 interacting genes: ALYREF CEP70 CORO1A CPSF7 DPH2 DPPA4 EIF4A3 FXR1 GOLGA2 IPO13 MAP1B NXF1 PPP1R16B PTBP2 RBM8A TADA2A TFIP11 UPF3B XIST YWHAQ ZKSCAN8 ZRANB1	245 interacting genes: ABT1 AGBL2 AKAP17A ARHGEF3 ARMCX1 ATOSB ATP5PO ATXN7 BARD1 BAZ2B BEX2 BRD1 BRMS1 BRMS1L BRPF1 BYSL C1orf35 C7orf25 C8orf33 CARD9 CAVIN3 CBX8 CCDC187 CCDC85B CDC37 CDC73 CDCA7L CEP57L1 CFAP53 CLPB COIL CWF19L2 DAXX DAZAP2 DDX41 DDX6 DNAJB11 DNTTIP2 DRC4 DVL3 DYRK1A EAF1 EBNA1BP2 EIF3D ELOA ELOA2 EMD EMP1 ENKD1 ERCC3 FAM118B FAM124A FAM133A FAM13C FAM161A FAM161B FAM90A1 GADD45GIP1 GATAD2B GCC1 GEM GLYCTK GPATCH2L GPATCH4 GPX7 GSE1 HAUS1 HDAC4 HDAC6 HIC2 HMGB4 HOXB5 HOXC8 HSPD1 IK INO80B INPP5J IPCEF1 IQCE IQUB ITPKB KANK2 KANSL1 KAT14 KAT5 KAT7 KDM1A KRI1 KRT31 LAMTOR5 LCOR LENG1 LENG8 LIN37 LNX1 MAB21L2 MAGOH MBD3 MCM10 MCRS1 MEST METTL17 MFAP1 MKRN3 MRPL44 NEBL NIPSNAP3A NKAP NKAPD1 NOL12 NOP2 NOP53 NOXA1 NRIP1 NTAQ1 NUSAP1 ODAD4 PAM16 PIBF1 PIMREG PKN1 PLA2G2A PPFIA1 PPIG PPP1R16B PPP1R18 PRKRIP1 PRPF18 PRPF3 PRPF31 PSMA1 PSORS1C2 RASSF10 RBM10 RCOR3 RHPN1 RNF169 RNF6 RPL13 SCNM1 SEC14L1 SERPINH1 SETD5 SFR1 SH2D4A SLU7 SMARCE1 SNRPD2 SNW1 SOD2 SPANXN3 SRGN SSX3 STK25 STMN2 SUV39H1 SUV39H2 SYT17 SYTL4 SYTL5 TAF1D TBC1D22B TBC1D30 TCAF1 TCEA2 TCEANC TEAD4 TLK2 TRAF3IP3 TRIM29 TRIM3 TRIM42 TSFM TSGA10IP TSHZ3 TTLL10 TXLNB TXN2 USP2 UTP11 UTP14A UTP14C UTP25 UTP3 VXN WT1 YJU2 ZBTB16 ZBTB24 ZBTB4 ZBTB47 ZBTB48 ZBTB49 ZBTB8A ZCCHC10 ZFC3H1 ZFHX3 ZFP1 ZFP91 ZGPAT ZNF136 ZNF140 ZNF148 ZNF165 ZNF169 ZNF17 ZNF20 ZNF202 ZNF227 ZNF239 ZNF250 ZNF264 ZNF266 ZNF302 ZNF329 ZNF35 ZNF366 ZNF408 ZNF410 ZNF417 ZNF426 ZNF433 ZNF439 ZNF490 ZNF491 ZNF555 ZNF557 ZNF572 ZNF574 ZNF578 ZNF587 ZNF599 ZNF607 ZNF648 ZNF669 ZNF688 ZNF696 ZNF775 ZNF777 ZNF785 ZNF835 ZNF860 ZSCAN12 ZSCAN21 ZSCAN23
Entrez ID		4116	80321
HPRD ID		04005	16779
Ensembl ID		ENSG00000162385	ENSG00000114107
Uniprot IDs		P61326	A0A140VJG2 B7Z2D2 Q8NHQ1
PDB IDs		1P27 2HYI 2J0Q 2J0S 2XB2 3EX7 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD
Enriched GO Terms of Interacting Partners?		MRNA Binding MRNA Transport Exon-exon Junction Complex Nucleic Acid Binding RNA Transport Nucleobase-containing Compound Transport MRNA Export From Nucleus Spliceosomal Complex RNA Export From Nucleus Catalytic Step 2 Spliceosome MRNA Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Nuclear Speck Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Processing Nuclear Export Cellular Localization RNA Binding Intracellular Transport Neuronal Cell Body RNA Splicing U2-type Catalytic Step 1 Spliceosome Transcription Export Complex Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleus Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell MRNA Catabolic Process RNA Processing Regulation Of MRNA Metabolic Process Induction Of Synaptic Plasticity By Chemical Substance Ribonucleoprotein Complex Binding Positive Regulation Of Translation Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion RNA Metabolic Process Regulation Of RNA Splicing Regulation Of Translation RNA Catabolic Process Organelle Assembly MRNA Splicing, Via Spliceosome 2-(3-amino-3-carboxypropyl)histidine Synthase Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Uropod Organization Spliceosomal Complex Disassembly RNA Splicing, Via Transesterification Reactions Dendrite	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nucleus Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleolus RNA Processing Nuclear Speck Spliceosomal Complex Nucleoplasm RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone Acetyltransferase Complex Chromatin Organization Nuclear Androgen Receptor Binding Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Chromosome Transcription Elongation By RNA Polymerase II RRNA Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Remodeling Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process RNA Binding DNA-templated Transcription Elongation RNA Metabolic Process Histone H3-K14 Acetyltransferase Complex MRNA Processing Ribonucleoprotein Complex Biogenesis RRNA Metabolic Process Nucleic Acid Metabolic Process
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