MAGOH and ZKSCAN8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAGOH	ZKSCAN8
Description		mago homolog, exon junction complex subunit	zinc finger with KRAB and SCAN domains 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14	Nucleus Cytosol
	Molecular Function	RNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus Regulation Of Translation RNA Splicing Regulation Of MRNA Processing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Generic Transcription Pathway
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alanine aminotransferase levels ( 33547301) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean corpuscular volume ( 27863252) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		22 interacting genes: ALYREF CEP70 CORO1A CPSF7 DPH2 DPPA4 EIF4A3 FXR1 GOLGA2 IPO13 MAP1B NXF1 PPP1R16B PTBP2 RBM8A TADA2A TFIP11 UPF3B XIST YWHAQ ZKSCAN8 ZRANB1	10 interacting genes: APP FBXO7 MAGOH OGT PRNP TCEA2 ZNF165 ZNF174 ZNF24 ZNF587
Entrez ID		4116	7745
HPRD ID		04005	03760
Ensembl ID		ENSG00000162385	ENSG00000198315
Uniprot IDs		P61326	Q15776 Q59HG5
PDB IDs		1P27 2HYI 2J0Q 2J0S 2XB2 3EX7 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD
Enriched GO Terms of Interacting Partners?		MRNA Binding MRNA Transport Exon-exon Junction Complex Nucleic Acid Binding RNA Transport Nucleobase-containing Compound Transport MRNA Export From Nucleus Spliceosomal Complex RNA Export From Nucleus Catalytic Step 2 Spliceosome MRNA Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Nuclear Speck Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Processing Nuclear Export Cellular Localization RNA Binding Intracellular Transport Neuronal Cell Body RNA Splicing U2-type Catalytic Step 1 Spliceosome Transcription Export Complex Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleus Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell MRNA Catabolic Process RNA Processing Regulation Of MRNA Metabolic Process Induction Of Synaptic Plasticity By Chemical Substance Ribonucleoprotein Complex Binding Positive Regulation Of Translation Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion RNA Metabolic Process Regulation Of RNA Splicing Regulation Of Translation RNA Catabolic Process Organelle Assembly MRNA Splicing, Via Spliceosome 2-(3-amino-3-carboxypropyl)histidine Synthase Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Uropod Organization Spliceosomal Complex Disassembly RNA Splicing, Via Transesterification Reactions Dendrite	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Cellular Response To Copper Ion Regulation Of Primary Metabolic Process Molecular Function Activator Activity Response To Copper Ion Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Neuron Apoptotic Process DNA Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Amyloid-beta Type 8 Metabotropic Glutamate Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Synapse Organization Regulation Of Carbohydrate Catabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process Autophagy Of Mitochondrion Regulation Of ATP Metabolic Process Nucleus
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