ZEB2 and CBX4

Number of citations of the paper that reports this interaction (PMID 16061479)
25

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		ZEB2	CBX4
Gene Name		zinc finger E-box binding homeobox 2	chromobox homolog 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Phosphatase Regulator Activity Metal Ion Binding R-SMAD Binding	Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Ligase Activity Enzyme Binding SUMO Binding Methylated Histone Binding Transcription Regulatory Region DNA Binding Phosphoprotein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Somitogenesis Neural Tube Closure Transcription, DNA-templated Nervous System Development Hippocampus Development Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Melanocyte Migration Regulation Of Melanosome Organization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Chromatin Modification Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Obesity-related traits ( 23251661) Renal cell carcinoma ( 23184150)
Protein-Protein Interactions		11 interactors: APP CBX4 COPS6 CTBP1 CTBP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I	18 interactors: CBS CSNK2B CTBP1 CTBP2 FHL1 HIST3H3 KMT2A LNX2 MBD1 MED9 RB1 RING1 RNF2 SATB1 SKIL SUV39H1 UBE2I ZEB2
Entrez ID		9839	8535
HPRD ID		05780	04357
Ensembl ID		ENSG00000169554	ENSG00000141582
Uniprot IDs		O60315	O00257
PDB IDs		2DA7	2K28 3I8Z
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Kidney Epithelium Development Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryonic Pattern Specification Production Of MiRNAs Involved In Gene Silencing By MiRNA Kidney Development Renal System Development Regulation Of Transcription, DNA-templated Urogenital System Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Gene Silencing By MiRNA Cellular Response To Organic Cyclic Compound Regulation Of RNA Metabolic Process Cellular Response To DsRNA RNA Metabolic Process Cellular Protein Modification Process Posttranscriptional Gene Silencing Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Gene Expression Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Osteoblast Fate Commitment Mullerian Duct Regression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Viral Process Skeletal System Development Gene Silencing By RNA Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Response To Growth Factor Regulation Of Binding Negative Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Chromatin Modification Histone Modification RNA Metabolic Process Chromosome Organization Cellular Nitrogen Compound Metabolic Process Chromatin Organization Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Histone H2A Monoubiquitination Anterior/posterior Pattern Specification Histone H2A Ubiquitination Cellular Metabolic Process Regulation Of Metabolic Process White Fat Cell Differentiation Developmental Process Histone Methylation Histone Monoubiquitination Negative Regulation Of Cell Proliferation Viral Genome Replication Organelle Organization Peptidyl-lysine Trimethylation Protein Methylation Histone Ubiquitination Cell Cycle Cell Differentiation Pattern Specification Process
Tagcloud ?		17q12 3d acinar acquisition amplicon anoikis coamplified disrupted emt enhances epithelial erbb2 escape foxc2 inducing mammary mcf10a mesenchymal overexpression polarity proliferative rara slug steps transformation transition tumorigenesis tumorigenic zeb1	3p accordingly bodies brachyury cbx7 chemicals ectodermal embryoid endodermal fgf5 foxa2 ideal markers meanwhile mebs mesodermal nanog nestin oct4 pcg perfluorooctane pfos pluripotency polycomb poses sma sox17 sox2 sulfonate
Tagcloud (Difference) ?		17q12 3d acinar acquisition amplicon anoikis coamplified disrupted emt enhances epithelial erbb2 escape foxc2 inducing mammary mcf10a mesenchymal overexpression polarity proliferative rara slug steps transformation transition tumorigenesis tumorigenic zeb1	3p accordingly bodies brachyury cbx7 chemicals ectodermal embryoid endodermal fgf5 foxa2 ideal markers meanwhile mebs mesodermal nanog nestin oct4 pcg perfluorooctane pfos pluripotency polycomb poses sma sox17 sox2 sulfonate
Tagcloud (Intersection) ?