ZEB2

Gene Name		zinc finger E-box binding homeobox 2
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Gene Ontology Annotations	Cellular Component	Nucleus
	Molecular Function	DNA Binding Phosphatase Regulator Activity Metal Ion Binding R-SMAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Somitogenesis Neural Tube Closure Transcription, DNA-templated Nervous System Development Hippocampus Development Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Melanocyte Migration Regulation Of Melanosome Organization
Pathways
Drugs
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Obesity-related traits ( 23251661) Renal cell carcinoma ( 23184150)
Protein-protein Interactions		11 interactors: APP CBX4 COPS6 CTBP1 CTBP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I
Entrez ID		9839
HPRD ID		05780
Ensembl ID		ENSG00000169554
Uniprot IDs		O60315
PDB IDs		2DA7
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Primary MiRNA Processing Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Kidney Epithelium Development Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryonic Pattern Specification Production Of MiRNAs Involved In Gene Silencing By MiRNA Kidney Development Renal System Development Regulation Of Transcription, DNA-templated Urogenital System Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Gene Silencing By MiRNA Cellular Response To Organic Cyclic Compound Regulation Of RNA Metabolic Process Cellular Response To DsRNA RNA Metabolic Process Cellular Protein Modification Process Posttranscriptional Gene Silencing Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Gene Expression Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Osteoblast Fate Commitment Mullerian Duct Regression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Viral Process Skeletal System Development Gene Silencing By RNA Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Response To Growth Factor Regulation Of Binding Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		17q12 3d acinar acquisition amplicon anoikis coamplified disrupted emt enhances epithelial erbb2 escape foxc2 inducing mammary mcf10a mesenchymal overexpression polarity proliferative rara slug steps transformation transition tumorigenesis tumorigenic zeb1