SOX7 and SCAI

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SOX7	SCAI
Description		SRY-box transcription factor 7	suppressor of cancer cell invasion
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Endoderm Formation Regulation Of Transcription By RNA Polymerase II Tissue Development Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis	DNA-templated Transcription Negative Regulation Of Signal Transduction Negative Regulation Of Cell Migration Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of DNA-templated Transcription
Pathways		Deactivation of the beta-catenin transactivating complex	RHO GTPases Activate Formins
Drugs
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Anxiety/tension (special factor of neuroticism) ( 30867560) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder ( 30804558) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Gut microbiota (beta diversity) ( 27723756) HDL cholesterol levels ( 32203549) Intracranial aneurysm ( 29531279) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Neutrophil percentage of white cells ( 32888494) Number of sexual partners ( 30643258) Processed meat consumption ( 32066663) Refractive error ( 32231278) Retinal vascular caliber ( 21060863) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)	Age at first sexual intercourse ( 34211149) Pulse pressure ( 28135244 30578418) Refractive error ( 32231278) Smoking cessation ( 33082346) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		5 interacting genes: APP GLRX3 SCAI SMAD5 SMAD7	6 interacting genes: CDIPT ITPKB ITSN1 OGT PIN1 SOX7
Entrez ID		83595	286205
HPRD ID		18087	12941
Ensembl ID		ENSG00000171056	ENSG00000173611
Uniprot IDs		Q9BT81	Q8N9R8
PDB IDs
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex Regulation Of Cell Migration Regulation Of Locomotion Regulation Of Cell Motility I-SMAD Binding Negative Regulation Of Rho Protein Signal Transduction SMAD Protein Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Blood Circulation Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellular Iron Ion Homeostasis Kidney Epithelium Development Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Negative Regulation Of Small GTPase Mediated Signal Transduction Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Regulation Of Rho Protein Signal Transduction Cytoplasm Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Fas Signaling Pathway Positive Regulation Of Chondrocyte Development Hindbrain Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Cell Junction Organization PTB Domain Binding Monoatomic Ion Homeostasis Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium	Glycerophospholipid Biosynthetic Process Phosphatidylinositol Metabolic Process Positive Regulation Of Cell Communication Regulation Of Neutrophil Apoptotic Process Phospholipid Biosynthetic Process Regulation Of Small GTPase Mediated Signal Transduction Common Myeloid Progenitor Cell Proliferation Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of Signaling Phosphatidylinositol Biosynthetic Process Inositol Trisphosphate Metabolic Process Inositol-1,4,5-trisphosphate 3-kinase Activity Negative Regulation Of Neutrophil Apoptotic Process Phosphoserine Residue Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Peptidyl-prolyl Isomerization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Phosphothreonine Residue Binding Glutamatergic Synapse Cis-trans Isomerase Activity Negative Regulation Of Protein Catabolic Process Positive Regulation Of Caveolin-mediated Endocytosis Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Caveolin-mediated Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Alcohol Binding Inositol Hexakisphosphate Kinase Activity Glycerophospholipid Metabolic Process Postsynaptic Endocytic Zone Positive Regulation Of Growth Hormone Secretion Regulation Of Transcription By Glucose Mitogen-activated Protein Kinase Kinase Binding Postsynaptic Actin Cytoskeleton Positive Thymic T Cell Selection Inositol Phosphate Biosynthetic Process GTPase Activating Protein Binding Ubiquitin Ligase Activator Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway NSL Complex
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