GDF6

Description		growth differentiation factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Identical Protein Binding
	Biological Process	Metanephros Development Apoptotic Process Epithelial Cell Migration BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Cell Migration Involved In Metanephros Development Fat Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of P38MAPK Cascade Retinal Cell Apoptotic Process
Pathways
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Klippel-Feil syndrome(KFS)
GWAS
Interacting Genes		5 interacting genes: BMPR1A BMPR1B BMPR2 SMAD1 SMAD5
Entrez ID		392255
HPRD ID		11002
Ensembl ID		ENSG00000156466
Uniprot IDs		A0A0S2A5D6 Q6KF10
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Osteoblast Differentiation Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Receptor Activity Cardiac Muscle Tissue Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Cartilage Development Cardiac Conduction System Development Stem Cell Differentiation BMP Binding Striated Muscle Tissue Development Muscle Tissue Development Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Bone Mineralization Osteoblast Fate Commitment Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Cell Differentiation Mullerian Duct Regression Tricuspid Valve Morphogenesis Intracellular Iron Ion Homeostasis Negative Regulation Of Muscle Cell Differentiation Transforming Growth Factor Beta Receptor Activity, Type I Negative Regulation Of Chondrocyte Proliferation Bone Development Regulation Of Cartilage Development Regulation Of Bone Mineralization Endochondral Bone Morphogenesis SMAD Protein Complex HFE-transferrin Receptor Complex Mitral Valve Morphogenesis Heteromeric SMAD Protein Complex DEAD/H-box RNA Helicase Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Reproductive Process Regulation Of Ossification Animal Organ Development Pharyngeal Arch Artery Morphogenesis Anatomical Structure Morphogenesis
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