GDF6 and BMPR1B

Number of citations of the paper that reports this interaction (PMID 9525338)
18

Data Source:
HPRD (in vitro)

		GDF6	BMPR1B
Gene Name		growth differentiation factor 6	bone morphogenetic protein receptor, type IB
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity Protein Homodimerization Activity	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding SMAD Binding Metal Ion Binding
	Biological Process	Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cell Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Retinal Cell Apoptotic Process	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation
Pathways			Signaling by BMP
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 20732626)
Protein-Protein Interactions		5 interactors: BMPR1A BMPR1B BMPR2 SMAD1 SMAD5	63 interactors: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1
Entrez ID		392255	658
HPRD ID		11002	04457
Ensembl ID		ENSG00000156466	ENSG00000138696
Uniprot IDs		Q6KF10	A8KAE3 O00238
PDB IDs			3MDY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Cartilage Development Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Pattern Specification Process Skeletal System Development Negative Regulation Of Chondrocyte Proliferation Bone Development Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction By Phosphorylation Regulation Of Bone Mineralization Osteoblast Fate Commitment Mullerian Duct Regression Mesoderm Formation Regulation Of Cartilage Development Mesoderm Morphogenesis Protein Phosphorylation Regulation Of Cell Differentiation Formation Of Primary Germ Layer Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Development Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Phosphorylation Intracellular Signal Transduction Tube Development Anatomical Structure Regression Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Gastrulation Cellular Response To BMP Stimulus Limb Development Anatomical Structure Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Sex Differentiation Chondrocyte Development Epithelium Development Embryo Development Phosphate-containing Compound Metabolic Process Single Organism Reproductive Process Organ Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Signaling Regulation Of Protein Phosphorylation Regulation Of Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Growth Factor Positive Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus SMAD Protein Signal Transduction Response To Transforming Growth Factor Beta Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stimulus Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Cellular Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Signal Transduction By Phosphorylation Regulation Of Cell Development Regulation Of Cellular Process Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Phosphorylation
Tagcloud ?		amongst argue bigenic bmp broadened broader degenerative disrupt disrupted effecting endurance gdf6a harboring junctions larval modifier morphogenetic neuromuscular nmj noting progressively siblings sod1 suite synergize vertebrate vertebrates worsened	125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Difference) ?		amongst argue bigenic bmp broadened broader degenerative disrupt disrupted effecting endurance gdf6a harboring junctions larval modifier morphogenetic neuromuscular nmj noting progressively siblings sod1 suite synergize vertebrate vertebrates worsened	125b acvr1b acvr2a arid3b bak1 bcl2l2 bear bim cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Intersection) ?