GDF6 and SMAD5

Number of citations of the paper that reports this interaction (PMID 15246821)
7

Data Source:
HPRD (in vitro)

		GDF6	SMAD5
Gene Name		growth differentiation factor 6	SMAD family member 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity Protein Homodimerization Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding
	Biological Process	Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cell Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Retinal Cell Apoptotic Process	Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways			Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BMPR1A BMPR1B BMPR2 SMAD1 SMAD5	44 interactors: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8
Entrez ID		392255	4090
HPRD ID		11002	04381
Ensembl ID		ENSG00000156466	ENSG00000113658
Uniprot IDs		Q6KF10	Q68DB7 Q99717
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Cartilage Development Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Pattern Specification Process Skeletal System Development Negative Regulation Of Chondrocyte Proliferation Bone Development Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction By Phosphorylation Regulation Of Bone Mineralization Osteoblast Fate Commitment Mullerian Duct Regression Mesoderm Formation Regulation Of Cartilage Development Mesoderm Morphogenesis Protein Phosphorylation Regulation Of Cell Differentiation Formation Of Primary Germ Layer Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Development Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Phosphorylation Intracellular Signal Transduction Tube Development Anatomical Structure Regression Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Gastrulation Cellular Response To BMP Stimulus Limb Development Anatomical Structure Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Sex Differentiation Chondrocyte Development Epithelium Development Embryo Development Phosphate-containing Compound Metabolic Process Single Organism Reproductive Process Organ Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation	BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Positive Regulation Of Gene Expression RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Signal Transduction Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ossification Embryonic Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Tagcloud ?		amongst argue bigenic bmp broadened broader degenerative disrupt disrupted effecting endurance gdf6a harboring junctions larval modifier morphogenetic neuromuscular nmj noting progressively siblings sod1 suite synergize vertebrate vertebrates worsened	1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way
Tagcloud (Difference) ?		amongst argue bigenic bmp broadened broader degenerative disrupt disrupted effecting endurance gdf6a harboring junctions larval modifier morphogenetic neuromuscular nmj noting progressively siblings sod1 suite synergize vertebrate vertebrates worsened	1beta affecting alkaloid anticancer bcl caspases cdk1 compound cytokines cytotoxicity g0 g1 inducing k562 lamd lamellarin leukemia marine p27 panel poorly pronounced smad3 stgc3 survivin tgf thinking understood way
Tagcloud (Intersection) ?