ESR1 and KDM5A

Number of citations of the paper that reports this interaction (PMID 11358960)
19

Data Source:
HPRD (in vitro)

		ESR1	KDM5A
Gene Name		estrogen receptor 1	lysine (K)-specific demethylase 5A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Membrane Integral Component Of Membrane Transcriptionally Active Chromatin	Nucleus Nucleoplasm Nucleolus Cytoplasm Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Steroid Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Nitric-oxide Synthase Regulator Activity Estrogen Receptor Activity Estrogen Response Element Binding Estrogen-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Identical Protein Binding	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors
	Biological Process	Antral Ovarian Follicle Growth Epithelial Cell Development Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Androgen Metabolic Process Male Gonad Development Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Response To Estradiol Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Estrogen Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Uterus Development Vagina Development Prostate Epithelial Cord Elongation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Mammary Gland Alveolus Development Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Cellular Response To Estradiol Stimulus	Chromatin Organization Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Chromatin Modification Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process Negative Regulation Of Histone Deacetylase Activity
Pathways		Nuclear signaling by ERBB4 Generic Transcription Pathway Nuclear Receptor transcription pathway Signaling by ERBB4	Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs		Diethylstilbestrol Chlorotrianisene Conjugated Estrogens Etonogestrel Desogestrel Levonorgestrel Progesterone Raloxifene Toremifene Medroxyprogesterone Estrone Tamoxifen Estradiol Ethynodiol Diacetate Clomifene Dienestrol Fulvestrant Norgestimate Ethinyl Estradiol Melatonin Trilostane Naloxone Fluoxymesterone Estramustine Mestranol Danazol Allylestrenol Genistein Compound 19 Compound 18 Compound 4-D 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol Estriol Estropipate Quinestrol Ospemifene 17-METHYL-17-ALPHA-DIHYDROEQUILENIN 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL RALOXIFENE CORE
Diseases
GWAS		Alcohol dependence ( 19581569) Bone mineral density ( 23437003) Bone mineral density (hip) ( 19079262 19801982 18445777) Bone mineral density (spine) ( 19079262 19801982 18445777) Breast cancer ( 22383897 21263130 19219042 23535729 23535733 20453838) Breast size ( 22747683) Chronic myeloid leukemia ( 21540461) Height ( 20881960 23563607) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		266 interactors: ACTN4 AHR AKAP13 AKT1 AKT2 AR ARHGEF15 ARNT ATAD2 BAG1 BCAR1 BCAS2 BDNF BRCA1 BTF3 CALM1 CALM2 CALM3 CAV1 CBLL1 CCNC CCND1 CCNH CCNT1 CDC25B CDK2 CDK7 CDK8 CDKN1A CEBPA CEBPB CHD9 CHUK CITED1 COPS5 CREBBP CSNK2B CTNNB1 CUEDC2 CUL4B DAP3 DDX5 DDX54 DNTTIP2 DUT EGFR EHMT2 EIF3I EP300 ERBB2 ESR2 ESRRA FHL2 FKBP4 FKBP5 FLII FOXO1 FOXO3 FOXO4 GADD45B GADD45G GNAI1 GNAI2 GNAI3 GRB2 GRIP1 GTF2B GTF2H1 HDAC4 HDAC5 HDAC9 HEXIM1 HNF4A HSP90AA1 HSP90AB1 HSPA4 HSPA8 IGF1R ING1 ISL1 ITGB3BP JUN JUNB JUND KAT5 KDM5A KIF1A KLF5 KMT2D LCK LCOR LDB1 LINC00312 LRIF1 MAPK1 MAPK14 MAPK3 MDM2 MED1 MED10 MED12 MED13 MED14 MED16 MED17 MED20 MED21 MED23 MED24 MED25 MED6 MED7 MEN1 MGMT MKNK2 MMS19 MNAT1 MPG MSH2 MTA1 MTA2 MTA3 MTCH2 MUC1 MVP NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOA7 NCOR1 NCOR2 NELFB NFKB1 NPPA NR0B1 NR0B2 NR1H4 NR2C1 NR2C2 NR2F1 NR2F6 NRIP1 NSD1 OTUB1 PAGR1 PAK1 PAK6 PELP1 PGC PGR PHB PHB2 PIAS1 PIAS2 PIAS3 PIK3R1 PIK3R3 PNRC2 POLR1B POLR2D POU2F1 POU2F2 POU4F1 POU4F2 PPARG PPARGC1A PPARGC1B PPID PRDM2 PRKACA PRMT1 PRMT2 PRPF6 PSMC5 PTEN PTGES3 PTMA PTPN1 PTPN6 RAC3 RANBP9 RARA RBBP4 RBBP7 RBFOX2 RBM23 RBM39 RELA REXO4 RFX4 RGS3 RLIM RNF14 RNF4 RPS6KA1 RPS6KA3 RXRA SAFB SAFB2 SETD7 SF1 SHC1 SKIL SKP2 SLC30A9 SMAD2 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCD1 SMARCD3 SMARCE1 SMURF1 SMYD2 SOS1 SP1 SP3 SRA1 SRC SREBF1 STAT5A STRN STUB1 SUMO1 SUV39H1 SUV420H1 SVIL TAB2 TADA3 TAF10 TAF1A TAF1B TAF2 TAP1 TBP TCF20 TDG THRA THRB TNFRSF14 TP53 TRAM1 TRIM24 TRIM25 TRIM28 TRIM59 TRIP4 TRRAP TSC2 TUBA1B TUBB UBE2I UIMC1 USF1 VAV3 WHSC1 WIPI1 XBP1 YWHAH YWHAQ ZBTB16 ZBTB17 ZNF398	10 interactors: ESR1 HIST2H3A HIST3H3 LMO2 NR3C1 RARA RB1 RBL1 TBP VDR
Entrez ID		2099	5927
HPRD ID		00589	08915
Ensembl ID		ENSG00000091831	ENSG00000073614
Uniprot IDs		G4XH65 P03372 Q9UBT1	P29375
PDB IDs		1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2B1Z 2B23 2BJ4 2FAI 2G44 2G5O 2I0J 2IOG 2IOK 2JF9 2JFA 2LLO 2LLQ 2OCF 2OUZ 2P15 2POG 2Q6J 2Q70 2QA6 2QA8 2QAB 2QE4 2QGT 2QGW 2QH6 2QR9 2QSE 2QXM 2QXS 2QZO 2R6W 2R6Y 2YAT 2YJA 3CBM 3CBO 3CBP 3DT3 3ERD 3ERT 3HLV 3HM1 3L03 3OS8 3OS9 3OSA 3Q95 3Q97 3UU7 3UUA 3UUC 3UUD 4AA6 4DMA 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4JC3 4JDD	2JXJ 2KGG 2KGI 3GL6
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Gene Expression RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intracellular Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Response To Hormone Response To Organic Substance Cellular Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Cellular Response To Hormone Stimulus Androgen Receptor Signaling Pathway Signal Transduction Response To Stimulus Developmental Process	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Regulation Of Lipid Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Hormone-mediated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Mammary Gland Branching Involved In Pregnancy Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Kinase Activity Mammary Gland Duct Morphogenesis Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Mammary Gland Morphogenesis Tube Development Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Mammary Gland Epithelium Development Multicellular Organismal Reproductive Process Cellular Macromolecule Biosynthetic Process Multicellular Organism Reproduction Macromolecule Biosynthetic Process Epithelial Tube Morphogenesis Cellular Response To Organic Cyclic Compound
Tagcloud ?		analyzing brca1 carcinogenic changed characters coactivator concordant conduct differentiationassociated discovered downloaded e2 enrichment estradiol go gses9623 gsm986085 gsm986087 guidance macs mcf7 omnibus ontology p300bound p300regulated participated peakcalling software theoretical	blast blastic bp called cml demethylase demethylating downregulated epigenetically fatal h3k4 inhibits jarid1a leukemia locus lysine mir myeloid pdcd4 poorly rbp2 responds stimulates transformation treatments trimethylated turn underexpressed usually
Tagcloud (Difference) ?		analyzing brca1 carcinogenic changed characters coactivator concordant conduct differentiationassociated discovered downloaded e2 enrichment estradiol go gses9623 gsm986085 gsm986087 guidance macs mcf7 omnibus ontology p300bound p300regulated participated peakcalling software theoretical	blast blastic bp called cml demethylase demethylating downregulated epigenetically fatal h3k4 inhibits jarid1a leukemia locus lysine mir myeloid pdcd4 poorly rbp2 responds stimulates transformation treatments trimethylated turn underexpressed usually
Tagcloud (Intersection) ?