HOXC8 and KRT36

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOXC8	KRT36
Description		homeobox C8	keratin 36
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Microtubule Cytoskeleton	Cytosol Cytoskeleton Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Neuron Differentiation Skeletal System Morphogenesis	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization Regulation Of Keratinocyte Differentiation
Pathways		Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		108 interacting genes: ACTMAP ADAMTSL4 AIRIM ANKS1A BLZF1 BMPR1A BTG2 CADPS CCM2 CEP70 CFAP68 CRYBA1 CYSRT1 DLX2 DLX5 DVL3 DZIP3 ECM1 FNTB GMNN GOLGA6L9 GSTO2 GYS1 HESX1 HOMEZ HOXD3 HSF2BP IKZF3 JUN KCTD9 KHDC1 KPRP KRT31 KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-3 KRTAP19-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LDLRAP1 LDOC1 LHX2 LHX3 LRP2BP MAPK8IP2 MEOX1 MEOX2 METTL15 MGAT5B MSX1 NADSYN1 NBPF19 NFKBID NID2 NOTCH2NLA OIP5 PAX5 PAX6 PAX8 PBX1 PBX2 PBX4 PDE4DIP PFDN5 PLA2G10 PLEKHG4 POU2AF1 POU6F2 PPARA PRDM14 PRDM6 RBCK1 RBPMS SLAIN1 SMAD1 SMAD4 SMAD6 SNX17 TBC1D1 TBX19 TBX22 TEKT4 TLE5 TNS2 TRAF1 TRIB3 TRIM27 TRIM42 TRIP6 TSC1 USP54 VENTX WWOX ZFP90 ZMAT5 ZNF34 ZRANB1	60 interacting genes: ABI2 ABI3 AIMP2 AMOT APP BCAS2 C1orf216 CCBE1 CCHCR1 CDC23 DMRT3 EXOC8 GEM GPS2 HCK HGS HOXC8 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 MAP3K1 MYOZ1 MYOZ3 PKN1 PLEKHN1 PPP1R18 PSMB1 QARS1 RESF1 RIBC1 SMURF1 TMSB4X TRAF4 TSGA10IP TTC23 TTLL10 TXLNA ZNF414 ZNF785
Entrez ID		3224	8689
HPRD ID		00856	05174
Ensembl ID		ENSG00000037965	ENSG00000126337
Uniprot IDs		P31273	O76013
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Pituitary Gland Development Positive Regulation Of RNA Metabolic Process Regionalization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding SMAD Protein Signal Transduction Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Gland Development Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Sensory Organ Development Animal Organ Development Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Tissue Development Cardiac Conduction System Development Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Transcription Cis-regulatory Region Binding Epithelial Cell Differentiation DNA Binding Heteromeric SMAD Protein Complex Cell Fate Specification BMP Signaling Pathway Sequence-specific Double-stranded DNA Binding Epithelium Development R-SMAD Binding Cell Differentiation Embryonic Pattern Specification	Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Keratin Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Cytosol Protein Binding Extracellular Exosome Epidermis Development Intermediate Filament Cytoskeleton Cornified Envelope FATZ Binding Tissue Development Telethonin Binding Actin-based Cell Projection Structural Constituent Of Cytoskeleton Aminoacyl-tRNA Synthetase Multienzyme Complex SCAR Complex Developmental Process Regulation Of Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation
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