HOXC8 and TBX22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOXC8	TBX22
Description		homeobox C8	T-box transcription factor 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Microtubule Cytoskeleton	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Neuron Differentiation Skeletal System Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways		Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription
Drugs
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Cleft palate with ankyloglossia
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Nose size ( 27182965)
Interacting Genes		108 interacting genes: ACTMAP ADAMTSL4 AIRIM ANKS1A BLZF1 BMPR1A BTG2 CADPS CCM2 CEP70 CFAP68 CRYBA1 CYSRT1 DLX2 DLX5 DVL3 DZIP3 ECM1 FNTB GMNN GOLGA6L9 GSTO2 GYS1 HESX1 HOMEZ HOXD3 HSF2BP IKZF3 JUN KCTD9 KHDC1 KPRP KRT31 KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-3 KRTAP19-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LDLRAP1 LDOC1 LHX2 LHX3 LRP2BP MAPK8IP2 MEOX1 MEOX2 METTL15 MGAT5B MSX1 NADSYN1 NBPF19 NFKBID NID2 NOTCH2NLA OIP5 PAX5 PAX6 PAX8 PBX1 PBX2 PBX4 PDE4DIP PFDN5 PLA2G10 PLEKHG4 POU2AF1 POU6F2 PPARA PRDM14 PRDM6 RBCK1 RBPMS SLAIN1 SMAD1 SMAD4 SMAD6 SNX17 TBC1D1 TBX19 TBX22 TEKT4 TLE5 TNS2 TRAF1 TRIB3 TRIM27 TRIM42 TRIP6 TSC1 USP54 VENTX WWOX ZFP90 ZMAT5 ZNF34 ZRANB1	6 interacting genes: APP HOXC8 PITX1 PROP1 TLX3 VENTX
Entrez ID		3224	50945
HPRD ID		00856	02253
Ensembl ID		ENSG00000037965	ENSG00000122145
Uniprot IDs		P31273	B3KUL8 Q9Y458
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Pituitary Gland Development Positive Regulation Of RNA Metabolic Process Regionalization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding SMAD Protein Signal Transduction Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Gland Development Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Sensory Organ Development Animal Organ Development Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Tissue Development Cardiac Conduction System Development Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Transcription Cis-regulatory Region Binding Epithelial Cell Differentiation DNA Binding Heteromeric SMAD Protein Complex Cell Fate Specification BMP Signaling Pathway Sequence-specific Double-stranded DNA Binding Epithelium Development R-SMAD Binding Cell Differentiation Embryonic Pattern Specification	Sequence-specific Double-stranded DNA Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Cellular Developmental Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Pituitary Gland Development Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process System Development Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Acetylcholine Receptor Activator Activity Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of RNA Metabolic Process Lipoprotein Particle Developmental Process Positive Regulation Of Protein Import Hypophysis Morphogenesis PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Macromolecule Metabolic Process Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Branchiomeric Skeletal Muscle Development Myoblast Fate Commitment DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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