HOXC8 and TEKT4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOXC8	TEKT4
Description		homeobox C8	tektin 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Microtubule Cytoskeleton	Nucleus Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Neuron Differentiation Skeletal System Morphogenesis	Cell Projection Organization Flagellated Sperm Motility Cilium Assembly Cilium Movement Involved In Cell Motility
Pathways		Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Parkinson's disease ( 34064523)
Interacting Genes		108 interacting genes: ACTMAP ADAMTSL4 AIRIM ANKS1A BLZF1 BMPR1A BTG2 CADPS CCM2 CEP70 CFAP68 CRYBA1 CYSRT1 DLX2 DLX5 DVL3 DZIP3 ECM1 FNTB GMNN GOLGA6L9 GSTO2 GYS1 HESX1 HOMEZ HOXD3 HSF2BP IKZF3 JUN KCTD9 KHDC1 KPRP KRT31 KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-3 KRTAP19-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LDLRAP1 LDOC1 LHX2 LHX3 LRP2BP MAPK8IP2 MEOX1 MEOX2 METTL15 MGAT5B MSX1 NADSYN1 NBPF19 NFKBID NID2 NOTCH2NLA OIP5 PAX5 PAX6 PAX8 PBX1 PBX2 PBX4 PDE4DIP PFDN5 PLA2G10 PLEKHG4 POU2AF1 POU6F2 PPARA PRDM14 PRDM6 RBCK1 RBPMS SLAIN1 SMAD1 SMAD4 SMAD6 SNX17 TBC1D1 TBX19 TBX22 TEKT4 TLE5 TNS2 TRAF1 TRIB3 TRIM27 TRIM42 TRIP6 TSC1 USP54 VENTX WWOX ZFP90 ZMAT5 ZNF34 ZRANB1	105 interacting genes: ACBD4 AIRIM AKAP8L ALAS1 AMMECR1 ANKRD55 ARID5A ATG5 BCL6 BLZF1 BORCS8-MEF2B CFAP68 CTDSP1 DDIT4L EFHC2 EYA2 FAM220A GATA1 GPSM1 GRB10 GSE1 HCK HDAC6 HNRNPH1 HNRNPM HOXA1 HOXB5 HOXC8 IKZF3 INCA1 KPRP KRT15 KRT18 KRT34 KRT35 KRT75 KRT86 KRTAP11-1 KRTAP13-1 KRTAP13-3 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP26-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LASP1 LMCD1 LNX1 MAGEA4 MIIP MORN3 MYOZ3 NANOS3 NFKBID NR5A1 PCSK5 PHF11 PKP2 PLAGL2 POLDIP3 PPP1R13B PRDM14 PRDM6 PROP1 PSMA1 PTH1R RAMAC RARA RBM48 RECK RFX6 RUSC1 SAXO4 SCN5A SLC25A6 SMAD3 SOCS4 SPATA8 SPATC1L SPG21 SPMIP6 SUV39H1 TADA2A TEKT1 TFAP4 TOX2 TRIB3 TRIP6 TSPAN4 UBASH3A USP2 VGLL1 ZFP90 ZIM2 ZMYND12 ZNF20 ZNF417 ZNF426 ZNF474 ZNF552 ZNF581 ZNF655 ZNF688
Entrez ID		3224	150483
HPRD ID		00856	14518
Ensembl ID		ENSG00000037965	ENSG00000163060
Uniprot IDs		P31273	A0A384MEB7 Q8WW24
PDB IDs			7UNG
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Pituitary Gland Development Positive Regulation Of RNA Metabolic Process Regionalization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding SMAD Protein Signal Transduction Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Gland Development Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Sensory Organ Development Animal Organ Development Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Tissue Development Cardiac Conduction System Development Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Transcription Cis-regulatory Region Binding Epithelial Cell Differentiation DNA Binding Heteromeric SMAD Protein Complex Cell Fate Specification BMP Signaling Pathway Sequence-specific Double-stranded DNA Binding Epithelium Development R-SMAD Binding Cell Differentiation Embryonic Pattern Specification	Intermediate Filament Protein Binding Keratin Filament Nucleus Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Axonemal A Tubule Inner Sheath Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intermediate Filament Organization Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding DNA-binding Transcription Factor Activity Chromatin DNA Binding Structural Molecule Activity Histone Deacetylase Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Flagellated Sperm Motility Sperm Motility DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cilium-dependent Cell Motility Sperm Flagellum Regulation Of Primary Metabolic Process Cilium Movement Involved In Cell Motility Nucleoplasm Sequence-specific Double-stranded DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Sequence-specific DNA Binding Cilium Movement Negative Regulation Of RNA Metabolic Process Keratinization Erythrocyte Development
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