HOXC8 and DLX5

Number of citations of the paper that reports this interaction (PMID 9111364)
61

Data Source:
BioGRID (pull down)

		HOXC8	DLX5
Gene Name		homeobox C8	distal-less homeobox 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Microtubule Cytoskeleton	Nuclear Chromatin Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Regulatory Region DNA Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Anterior/posterior Pattern Specification Neuron Differentiation Skeletal System Morphogenesis	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Transcription, DNA-templated Nervous System Development Axon Guidance Cell Proliferation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Palate Development Olfactory Pit Development Face Morphogenesis Cellular Response To BMP Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: BMPR1A BTG2 DLX2 DLX5 GMNN HOMEZ JUN MSX1 SMAD1 SMAD4 SMAD6	9 interactors: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN
Entrez ID		3224	1749
HPRD ID		00856	02492
Ensembl ID			ENSG00000105880
Uniprot IDs		P31273	P56178 Q53Y73
PDB IDs			2DJN
Enriched GO Terms of Interacting Partners?		BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Organ Development Regulation Of RNA Metabolic Process Response To Transforming Growth Factor Beta Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Proliferation Regulation Of Gene Expression Endocardial Cushion Formation Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Organ Morphogenesis Endocardial Cushion Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Response To Growth Factor Epithelium Development Palate Development Embryonic Morphogenesis Embryo Development Negative Regulation Of Cell Proliferation System Development Endocardial Cushion Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Head Development RNA Metabolic Process Nervous System Development Multicellular Organismal Development Cell Differentiation Gene Expression Anatomical Structure Development Cartilage Development Generation Of Neurons Regulation Of Cell Differentiation	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Mesenchymal Cell Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Mesenchyme Development Activation Of Meiosis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process BMP Signaling Pathway Involved In Heart Development Connective Tissue Development Stem Cell Development Skeletal System Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Differentiation Nail Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Regulation Of Gliogenesis Transcription From RNA Polymerase II Promoter Odontogenesis Of Dentin-containing Tooth Enteric Nervous System Development Odontogenesis Organ Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Meiotic Nuclear Division Endocardial Cushion Formation RNA Metabolic Process Embryo Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Tagcloud ?		abrogates cdkn1b correlates cyclophilin33 cyp33 downregulation h3k4me3 h4 homeodomain hoxa9 implying isomerase lineage lost mediates mll mutually phd3 preferentially proline reinsertion repression rrm selectivity structurally switch transforming translocations trimethylated	acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx2 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby
Tagcloud (Difference) ?		abrogates cdkn1b correlates cyclophilin33 cyp33 downregulation h3k4me3 h4 homeodomain hoxa9 implying isomerase lineage lost mediates mll mutually phd3 preferentially proline reinsertion repression rrm selectivity structurally switch transforming translocations trimethylated	acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx2 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby
Tagcloud (Intersection) ?