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MAP2K4 and MAP3K4
Number of citations of the paper that reports this interaction (PubMedID
9841871
)
44
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, in vivo)
MAP2K4
MAP3K4
Description
mitogen-activated protein kinase kinase 4
mitogen-activated protein kinase kinase kinase 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cytoplasm
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
JUN Kinase Kinase Activity
Kinase Activity
Transferase Activity
Molecular Adaptor Activity
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Apoptotic Process
Signal Transduction
JNK Cascade
Response To Wounding
Cellular Response To Stress
Smooth Muscle Cell Apoptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Fc-epsilon Receptor Signaling Pathway
Cellular Response To Mechanical Stimulus
Cellular Senescence
Negative Regulation Of Motor Neuron Apoptotic Process
MAPK Cascade
Placenta Development
Response To UV-C
Regulation Of Gene Expression
Male Germ-line Sex Determination
Positive Regulation Of Telomere Maintenance
Intracellular Signal Transduction
P38MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Chorionic Trophoblast Cell Differentiation
Positive Regulation Of P38MAPK Cascade
Pathways
Oxidative Stress Induced Senescence
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Uptake and function of anthrax toxins
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Pimasertib
Fostamatinib
Diseases
GWAS
Asthma (
32296059
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31152163
)
Response to amphetamines (
22952603
)
Serum alkaline phosphatase levels (
33339817
)
Aging (
22773346
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Lipoprotein (a) levels (
26377243
)
Ovarian disease with few adhesions (
28333195
)
Interacting Genes
44 interacting genes:
AKT1
ALDOB
APP
ARRB1
ARRB2
CFLAR
CYLC2
DUSP22
EFNA4
FBP2
FLNA
FLNC
GEMIN5
ITCH
JUN
LRRK2
MAP2K6
MAP3K1
MAP3K10
MAP3K11
MAP3K12
MAP3K14
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAP3K7
MAP3K8
MAP4K2
MAPK1
MAPK10
MAPK12
MAPK14
MAPK8
MAPK8IP3
MAPK9
NBR1
RBBP8
SPAG9
STX17
TRIB1
UBC
ZDHHC17
26 interacting genes:
ANXA2
AXIN1
BUB1B
CDC42
CHUK
CNTRL
DIXDC1
GADD45A
GADD45B
GADD45G
GSK3B
MAP2K1
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAPK13
MFHAS1
PTK2B
PTPN11
RAC1
RACGAP1
RUNX2
TPR
TRAF4
YWHAZ
Entrez ID
6416
4216
HPRD ID
03213
03886
Ensembl ID
ENSG00000065559
ENSG00000085511
Uniprot IDs
P45985
F5H538
J3KNB8
Q9P1M2
Q9Y6R4
PDB IDs
3ALN
3ALO
3VUT
8YP5
Enriched GO Terms of Interacting Partners
?
MAPK Cascade
MAP Kinase Kinase Kinase Activity
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Intracellular Signaling Cassette
Protein Kinase Activity
Kinase Activity
Regulation Of MAPK Cascade
Intracellular Signal Transduction
JNK Cascade
MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
ATP Binding
Protein Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Phosphorylation
Transferase Activity
Stress-activated MAPK Cascade
Signal Transduction
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Cytoplasm
Regulation Of Signal Transduction
Nucleotide Binding
JUN Kinase Kinase Kinase Activity
Protein Modification Process
Cytosol
P38MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Protein Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of JNK Cascade
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Fc-epsilon Receptor Signaling Pathway
Regulation Of Protein Modification Process
Positive Regulation Of JNK Cascade
Cellular Senescence
JUN Kinase Activity
Regulation Of MAP Kinase Activity
Phosphate-containing Compound Metabolic Process
Protein Autophosphorylation
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Protein Modification Process
Regulation Of Programmed Cell Death
Immune Response-regulating Signaling Pathway
Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Protein Kinase Binding
Regulation Of Intracellular Signal Transduction
Positive Regulation Of JNK Cascade
Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Signal Transduction
MAP Kinase Kinase Activity
Regulation Of JNK Cascade
Signal Transduction
Protein Kinase Activity
Intracellular Signaling Cassette
Regulation Of Cell Communication
Kinase Activity
Protein Tyrosine Kinase Activity
Cytoplasm
Protein Serine/threonine Kinase Activity
Apoptotic Process
Cellular Senescence
Protein Serine Kinase Activity
Nucleotide Binding
MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Programmed Cell Death
Cell Death
Positive Regulation Of P38MAPK Cascade
Cytosol
Cell Surface Receptor Signaling Pathway
Thioesterase Binding
ATP Binding
Regulation Of P38MAPK Cascade
Regulation Of Organelle Organization
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Protein Modification Process
Developmental Process
Cellular Response To Sorbitol
JUN Kinase Kinase Activity
Regulation Of Cell Cycle
Response To Stress
Transferase Activity
Regulation Of Protein Modification Process
Regulation Of ERK1 And ERK2 Cascade
Cellular Developmental Process
Cytoskeleton
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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