MAP2K4 and ZDHHC17

Number of citations of the paper that reports this interaction (PubMedID 31938047)
50

Data Source:
BioGRID (pull down, pull down)

		MAP2K4	ZDHHC17
Description		mitogen-activated protein kinase kinase 4	zDHHC palmitoyltransferase 17
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Kinase Activity Transferase Activity Molecular Adaptor Activity Protein Serine Kinase Activity	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity
	Biological Process	MAPK Cascade Apoptotic Process Signal Transduction JNK Cascade Response To Wounding Cellular Response To Stress Smooth Muscle Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Fc-epsilon Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Cellular Senescence Negative Regulation Of Motor Neuron Apoptotic Process	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		Pimasertib
Diseases
GWAS		Asthma ( 32296059) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817)	Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)
Interacting Genes		44 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC ZDHHC17	192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9
Entrez ID		6416	23390
HPRD ID		03213	09697
Ensembl ID		ENSG00000065559	ENSG00000186908
Uniprot IDs		P45985	A8KA01 Q8IUH5
PDB IDs		3ALN 3ALO 3VUT 8YP5	3EU9 5W7I 5W7J
Enriched GO Terms of Interacting Partners?		MAPK Cascade MAP Kinase Kinase Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Protein Kinase Activity Kinase Activity Regulation Of MAPK Cascade Intracellular Signal Transduction JNK Cascade MAP Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction ATP Binding Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Phosphorylation Transferase Activity Stress-activated MAPK Cascade Signal Transduction Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Cytoplasm Regulation Of Signal Transduction Nucleotide Binding JUN Kinase Kinase Kinase Activity Protein Modification Process Cytosol P38MAPK Cascade Positive Regulation Of JUN Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of JNK Cascade Cellular Senescence JUN Kinase Activity Regulation Of MAP Kinase Activity Phosphate-containing Compound Metabolic Process Protein Autophosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway	Protein Binding
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