MAP2K4 and MAP3K12

Number of citations of the paper that reports this interaction (PMID 10187804)
19

Data Source:
HPRD (in vitro)

		MAP2K4	MAP3K12
Gene Name		mitogen-activated protein kinase kinase 4	mitogen-activated protein kinase kinase kinase 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon	Cytoplasm Cytosol Plasma Membrane Membrane Axon Growth Cone
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Pathogenesis Peptidyl-tyrosine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of DNA Replication Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Uptake and actions of bacterial toxins MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Uptake and function of anthrax toxins Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling
Drugs
Diseases
GWAS		Response to amphetamines ( 22952603)
Protein-Protein Interactions		37 interactors: AKT1 APP ARRB1 ARRB2 CFLAR DUSP22 EFNA4 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 RBBP8 SPAG9 TRIB1 ZAK	15 interactors: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP RGS1 RPL18A SH3RF1 TGM2 TSC22D1
Entrez ID		6416	7786
HPRD ID		03213	02709
Ensembl ID		ENSG00000065559	ENSG00000139625
Uniprot IDs		B7ZA62 P45985	Q12852
PDB IDs		3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Regulation Of MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Activation Of MAPK Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process JNK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Phosphorylation Regulation Of Signaling Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Phosphate-containing Compound Metabolic Process Positive Regulation Of JUN Kinase Activity Cell Death Death Positive Regulation Of JNK Cascade Regulation Of JUN Kinase Activity	MAPK Cascade Signal Transduction By Phosphorylation Regulation Of JNK Cascade Regulation Of MAPK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Catalytic Activity Activation Of JUN Kinase Activity Cellular Response To Sorbitol Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Death Positive Regulation Of Transferase Activity Positive Regulation Of Apoptotic Process Activation Of Protein Kinase Activity Positive Regulation Of Programmed Cell Death Cellular Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Death Cellular Protein Metabolic Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of JNK Cascade
Tagcloud ?		aurka aurkb bioinformatics cdkn2a copy custom describing epha5 flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable	adipocytes adipogenesis adipogenic adipose ascs bisphenol bpa ccaat cebpa disrupter dlk dye ebpalpha esr1 ici igf1 leucine lipase lpl peroxisome physiologically pparg ppargamma precursors proliferator retained temporally visualize zipper
Tagcloud (Difference) ?		aurka aurkb bioinformatics cdkn2a copy custom describing epha5 flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable	adipocytes adipogenesis adipogenic adipose ascs bisphenol bpa ccaat cebpa disrupter dlk dye ebpalpha esr1 ici igf1 leucine lipase lpl peroxisome physiologically pparg ppargamma precursors proliferator retained temporally visualize zipper
Tagcloud (Intersection) ?