MAP2K4 and MAP3K10

Number of citations of the paper that reports this interaction (PMID 9182538)
26

Data Source:
HPRD (in vitro)

		MAP2K4	MAP3K10
Gene Name		mitogen-activated protein kinase kinase 4	mitogen-activated protein kinase kinase kinase 10
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon	Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Pathogenesis Peptidyl-tyrosine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of DNA Replication Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Uptake and actions of bacterial toxins MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Uptake and function of anthrax toxins Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling
Drugs
Diseases
GWAS		Response to amphetamines ( 22952603)
Protein-Protein Interactions		37 interactors: AKT1 APP ARRB1 ARRB2 CFLAR DUSP22 EFNA4 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 RBBP8 SPAG9 TRIB1 ZAK	30 interactors: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS HGS HTT KIAA1804 KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 TUBB YWHAE
Entrez ID		6416	4294
HPRD ID		03213	02533
Ensembl ID		ENSG00000065559	ENSG00000130758
Uniprot IDs		B7ZA62 P45985	Q02779
PDB IDs		3ALN 3ALO 3VUT	2RF0
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Regulation Of MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Activation Of MAPK Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process JNK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Phosphorylation Regulation Of Signaling Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Phosphate-containing Compound Metabolic Process Positive Regulation Of JUN Kinase Activity Cell Death Death Positive Regulation Of JNK Cascade Regulation Of JUN Kinase Activity	Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component Signal Transduction Regulation Of Signal Transduction Regulation Of Stress-activated MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signaling Regulation Of Signaling Cell Communication Neurogenesis Cell Differentiation Regulation Of JNK Cascade Generation Of Neurons Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of MAPK Cascade Organelle Organization Cellular Localization Cellular Response To Stimulus Neuron Differentiation Response To Stimulus Regulation Of Apoptotic Process Developmental Process Organelle Transport Along Microtubule Regulation Of Phosphorus Metabolic Process MAPK Cascade Response To Stress Intracellular Transport Regulation Of Cell Death Protein Localization Nervous System Development Cytoskeleton-dependent Intracellular Transport Regulation Of Body Fluid Levels Positive Regulation Of Intracellular Signal Transduction Plus-end-directed Vesicle Transport Along Microtubule Wound Healing Regulation Of Catalytic Activity Signal Transduction By Phosphorylation Membrane Organization Transport JNK Cascade Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Microtubule-based Movement Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule Response To Wounding
Tagcloud ?		aurka aurkb bioinformatics cdkn2a copy custom describing epha5 flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		aurka aurkb bioinformatics cdkn2a copy custom describing epha5 flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses multiplexed nf1 ngs notch1 pdgfrb pipeline rationale rb1 sarcomas soft stratification targetable	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 merits mmp1 nfkb1a nos2a partp polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?		pik3ca