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MAP2K4 and MAPK9
Number of citations of the paper that reports this interaction (PubMedID
11062067
)
16
Data Source:
HPRD
(in vitro, in vivo)
MAP2K4
MAPK9
Description
mitogen-activated protein kinase kinase 4
mitogen-activated protein kinase 9
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Nuclear Speck
Schaffer Collateral - CA1 Synapse
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
JUN Kinase Kinase Activity
Kinase Activity
Transferase Activity
Molecular Adaptor Activity
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Apoptotic Process
Signal Transduction
JNK Cascade
Response To Wounding
Cellular Response To Stress
Smooth Muscle Cell Apoptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Fc-epsilon Receptor Signaling Pathway
Cellular Response To Mechanical Stimulus
Cellular Senescence
Negative Regulation Of Motor Neuron Apoptotic Process
MAPK Cascade
Protein Phosphorylation
JNK Cascade
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Reactive Oxygen Species
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Regulation Of MRNA Stability
Response To Cadmium Ion
Rhythmic Process
Modulation Of Chemical Synaptic Transmission
MRNA Destabilization
Protein Localization To Tricellular Tight Junction
Positive Regulation Of Podosome Assembly
Cellular Senescence
Inflammatory Response To Wounding
Apoptotic Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Oxidative Stress Induced Senescence
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Uptake and function of anthrax toxins
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Signaling by ALK fusions and activated point mutants
Drugs
Pimasertib
Minocycline
N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide
Fostamatinib
Halicin
Diseases
GWAS
Asthma (
32296059
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31152163
)
Response to amphetamines (
22952603
)
Serum alkaline phosphatase levels (
33339817
)
Appendicular lean mass (
33097823
)
Blood protein levels (
30072576
)
Interacting Genes
44 interacting genes:
AKT1
ALDOB
APP
ARRB1
ARRB2
CFLAR
CYLC2
DUSP22
EFNA4
FBP2
FLNA
FLNC
GEMIN5
ITCH
JUN
LRRK2
MAP2K6
MAP3K1
MAP3K10
MAP3K11
MAP3K12
MAP3K14
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAP3K7
MAP3K8
MAP4K2
MAPK1
MAPK10
MAPK12
MAPK14
MAPK8
MAPK8IP3
MAPK9
NBR1
RBBP8
SPAG9
STX17
TRIB1
UBC
ZDHHC17
111 interacting genes:
ACP5
AKT1
ARRB1
ARRB2
ATF2
ATF7
BCL2L1
BCL2L11
BTRC
C1orf105
C1orf94
CASP3
CBLL2
CCDC33
CDC16
CDC25B
CDC25C
CEP126
CEP44
CLU
CTBP1
CTNNB1
DCX
DTX3
DUSP10
DUSP16
DUSP19
DUSP4
EEF2K
EFHC2
EGFR
ELK1
ELK3
ENKD1
FBXO7
GFAP
GOLGA6A
GRB2
GSC2
H3-3A
HDAC9
HSF1
IHO1
IRS1
ITGB3BP
JDP2
JUN
JUNB
JUND
KLHL8
KPNA3
L3MBTL3
LHX3
LMAN2
LNX1
LNX2
LZTS1
MACF1
MAP2K4
MAP2K7
MAP3K1
MAP3K10
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAPK5
MAPKBP1
MAPT
MCRS1
MED12L
MEOX1
MLIP
NCF1
NCSTN
NFATC3
NFATC4
NHSL2
PAX5
PBX4
PICK1
POU6F2
PPARG
PRKD1
PSEN1
RB1
RPS6KB1
RSPO4
SAXO1
SDCBP
SF3B4
SH3BP5
SHMT1
SMAD2
SMAD3
SMCO3
SSU72
TCP10L
TEX11
TOB1
TP53
TRAF2
TUSC2
WDR62
XPNPEP1
XPO7
ZBTB25
ZC2HC1C
ZFTRAF1
ZNF138
ZNF559
ZNHIT1
Entrez ID
6416
5601
HPRD ID
03213
04206
Ensembl ID
ENSG00000065559
ENSG00000050748
Uniprot IDs
P45985
D7R525
P45984
PDB IDs
3ALN
3ALO
3VUT
8YP5
3E7O
3NPC
7CML
7N8T
8ELC
Enriched GO Terms of Interacting Partners
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MAPK Cascade
MAP Kinase Kinase Kinase Activity
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Intracellular Signaling Cassette
Protein Kinase Activity
Kinase Activity
Regulation Of MAPK Cascade
Intracellular Signal Transduction
JNK Cascade
MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
ATP Binding
Protein Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Phosphorylation
Transferase Activity
Stress-activated MAPK Cascade
Signal Transduction
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Cytoplasm
Regulation Of Signal Transduction
Nucleotide Binding
JUN Kinase Kinase Kinase Activity
Protein Modification Process
Cytosol
P38MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Protein Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of JNK Cascade
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Fc-epsilon Receptor Signaling Pathway
Regulation Of Protein Modification Process
Positive Regulation Of JNK Cascade
Cellular Senescence
JUN Kinase Activity
Regulation Of MAP Kinase Activity
Phosphate-containing Compound Metabolic Process
Protein Autophosphorylation
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Protein Modification Process
Regulation Of Programmed Cell Death
Immune Response-regulating Signaling Pathway
Intracellular Signaling Cassette
Intracellular Signal Transduction
MAPK Cascade
Negative Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Protein Kinase Binding
Cellular Developmental Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Activity
Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Apoptotic Signaling Pathway
Nucleus
Positive Regulation Of Transcription By RNA Polymerase II
JNK Cascade
JUN Kinase Binding
Programmed Cell Death
Cell Death
Negative Regulation Of Apoptotic Process
Cytoplasm
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cell Population Proliferation
Regulation Of Macromolecule Metabolic Process
Protein Binding
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Neuron Apoptotic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Differentiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Primary Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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