M6PR and GGA3

Number of citations of the paper that reports this interaction (PMID 11387475)
97

Data Source:
HPRD (two hybrid, in vitro)

		M6PR	GGA3
Gene Name		mannose-6-phosphate receptor (cation dependent)	golgi-associated, gamma adaptin ear containing, ARF binding protein 3
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endosome Late Endosome Integral Component Of Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Trans-Golgi Network Endosome Membrane Clathrin Adaptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Mannose Binding Mannose Transmembrane Transporter Activity	Protein Binding ADP-ribosylation Factor Binding
	Biological Process	Receptor-mediated Endocytosis Signal Transduction Endosome To Lysosome Transport Mannose Transport	Intracellular Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process
Pathways		trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: GGA1 GGA2 GGA3 JUN PLIN3 REN	24 interactors: AFTPH AP1S2 ARF1 ARF3 BACE1 CDKN2A CLINT1 CLTC GGA1 GGA2 IGF2R M6PR PACS1 RAB5A RABEP1 RNF11 RPS27A STAB1 SYNRG TBC1D3 TSG101 UBC VPS11 VPS18
Entrez ID		4074	23163
HPRD ID		01106	10443
Ensembl ID		ENSG00000003056	ENSG00000125447
Uniprot IDs		P20645	A8K6I6 A8K6M0 Q9NZ52
PDB IDs		1JUQ	1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transport Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Cellular Response To Potassium Ion Starvation Response To CAMP Leading Edge Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Protein Localization Response To Organophosphorus Establishment Of Localization In Cell Response To Purine-containing Compound Regulation Of Protein Metabolic Process Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Protein Catabolic Process Cellular Localization Positive Regulation Of Monocyte Differentiation Drinking Behavior Response To CGMP Transport SMAD Protein Import Into Nucleus Positive Regulation By Host Of Viral Transcription Response To Lipopolysaccharide Negative Regulation By Host Of Viral Transcription Angiotensin Maturation Response To Molecule Of Bacterial Origin Regulation Of Angiotensin Metabolic Process Negative Regulation Of Protein Autophosphorylation Regulation Of Blood Volume By Renin-angiotensin Microglial Cell Activation Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Monocyte Differentiation Regulation Of Protein Catabolic Process Monocyte Differentiation Negative Regulation Of Viral Transcription Beta-amyloid Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Immobilization Stress Response To Bacterium Response To Drug Negative Regulation Of Neuroblast Proliferation	Vesicle-mediated Transport Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Transport Cellular Localization Intracellular Protein Transport Membrane Organization Viral Protein Processing Endocytosis Cellular Protein Localization Viral Process Virion Assembly Post-Golgi Vesicle-mediated Transport Endosomal Transport Regulation Of Defense Response To Virus By Virus Intracellular Transport Of Virus Antigen Processing And Presentation Of Peptide Antigen Golgi Vesicle Transport Antigen Processing And Presentation Receptor-mediated Endocytosis Viral Life Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle Arrest Membrane Budding Regulation Of Defense Response To Virus Protein Processing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Ubiquitin-protein Transferase Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Notch Receptor Processing Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Regulation Of Vesicle-mediated Transport G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Receptor Internalization Negative Regulation Of Cell Cycle Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Ubiquitination
Tagcloud ?		cathepsin compartment degraded dissociates distributed en endocytic endosome enriched fuse golgi hep internalized leaves lysosome lysosomes multivesicular mvb mvbs prelysosomal prelysosome pulse return route routed steady trans vacuolar vacuoles	acylation adaptin adaptors anchored apart cargo catalytically dileucine doi endosome governing hyperubiquitinated implicate itch knocked ll localizes onc participating publication put really recruits ribosylation rnf11 traffic ubiquitination vhs
Tagcloud (Difference) ?		cathepsin compartment degraded dissociates distributed en endocytic enriched fuse golgi hep internalized leaves lysosome lysosomes multivesicular mvb mvbs prelysosomal prelysosome pulse return route routed steady trans vacuolar vacuoles	acylation adaptin adaptors anchored apart cargo catalytically dileucine doi governing hyperubiquitinated implicate itch knocked ll localizes onc participating publication put really recruits ribosylation rnf11 traffic ubiquitination vhs
Tagcloud (Intersection) ?		endosome