M6PR and SMCO4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		M6PR	SMCO4
Name		mannose-6-phosphate receptor, cation dependent	single-pass membrane protein with coiled-coil domains 4
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Protein Transporter Activity Retromer Complex Binding	Protein Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Glycosphingolipid Catabolic Process	None
Pathways		Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Glycosphingolipid catabolism	None
Drugs		Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate	None
GWAS		Sjögren's syndrome ( 28076899 ) Total cholesterol levels ( 30275531 ) Type 1 diabetes ( 34127860 )	Adult body size ( 32376654 ) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273 ) Liver enzyme levels (alanine transaminase) ( 33972514 )
Novel Interactors		1 novel interactors: TMPRSS15	1 novel interactors: ATP2A2
Interacting Genes		12 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4	62 interacting genes: AQP6 ARL13B BNIP3L CD79A CLEC10A CLTRN CPLX4 CREB3L1 CXCR2 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FFAR2 GJA8 GKN1 GPA33 GPR152 GPR42 HHLA2 ICAM3 IL10RA KASH5 KCNK5 KIR3DL1 KRT40 KRTAP10-3 KRTAP10-7 LEPROTL1 LMNA LRRC25 M6PR MGST3 MS4A3 MUC1 PEX12 PLD3 PTGES RETREG3 SCN3B SLC10A6 SLC16A2 SLC18A1 SLC35H1 SLC41A3 SLC7A1 SLC7A14 SMIM3 SPINT1 STOM SUSD3 SYNE4 SYNPR TEX29 TFEC TMEM139 TMEM80 TMX2 VSIR WBP1
Entrez ID		4074	56935
HPRD ID		01106	17008
Ensembl ID		ENSG00000003056	ENSG00000166002
Uniprot IDs		F5GX30 P20645	Q9NRQ5
PDB IDs		1JUQ	Not available
GO Terms Enriched among Interactors		Endosome Membrane Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Endosome Trans-Golgi Network Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Macrophage Activation Golgi Vesicle Transport Small GTPase Binding Leading Edge Cell Differentiation Protein Localization To Membrane Cellular Response To Anisomycin Juxtaglomerular Apparatus Development Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Triglyceride Storage	Membrane Protein Binding