M6PR and GGA2

Number of citations of the paper that reports this interaction (PMID 11387475)
97

Data Source:
HPRD (two hybrid, in vitro)

		M6PR	GGA2
Gene Name		mannose-6-phosphate receptor (cation dependent)	golgi-associated, gamma adaptin ear containing, ARF binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endosome Late Endosome Integral Component Of Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin Adaptor Complex Clathrin-coated Vesicle
	Molecular Function	Transmembrane Signaling Receptor Activity Mannose Binding Mannose Transmembrane Transporter Activity	Protein Binding ADP-ribosylation Factor Binding
	Biological Process	Receptor-mediated Endocytosis Signal Transduction Endosome To Lysosome Transport Mannose Transport	Intracellular Protein Transport Vesicle-mediated Transport
Pathways		trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: GGA1 GGA2 GGA3 JUN PLIN3 REN	30 interactors: AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC GGA1 GGA3 HGS HTT IGF2R LRP3 M6PR PIN1 RAB5A RABEP1 RABGEF1 RNF11 SORL1 SORT1 SPG21 STAB1 SYNRG TRIM23 VPS18
Entrez ID		4074	23062
HPRD ID		01106	09347
Ensembl ID		ENSG00000003056	ENSG00000103365
Uniprot IDs		P20645	Q9UJY4
PDB IDs		1JUQ	1MHQ
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transport Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Cellular Response To Potassium Ion Starvation Response To CAMP Leading Edge Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Protein Localization Response To Organophosphorus Establishment Of Localization In Cell Response To Purine-containing Compound Regulation Of Protein Metabolic Process Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Protein Catabolic Process Cellular Localization Positive Regulation Of Monocyte Differentiation Drinking Behavior Response To CGMP Transport SMAD Protein Import Into Nucleus Positive Regulation By Host Of Viral Transcription Response To Lipopolysaccharide Negative Regulation By Host Of Viral Transcription Angiotensin Maturation Response To Molecule Of Bacterial Origin Regulation Of Angiotensin Metabolic Process Negative Regulation Of Protein Autophosphorylation Regulation Of Blood Volume By Renin-angiotensin Microglial Cell Activation Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Monocyte Differentiation Regulation Of Protein Catabolic Process Monocyte Differentiation Negative Regulation Of Viral Transcription Beta-amyloid Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Immobilization Stress Response To Bacterium Response To Drug Negative Regulation Of Neuroblast Proliferation See more	Vesicle-mediated Transport Endocytosis Intracellular Transport Protein Transport Establishment Of Protein Localization Transport Establishment Of Localization In Cell Protein Localization Cellular Localization Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Lysosomal Transport Golgi Vesicle Transport Vacuolar Transport Cellular Protein Localization Endosomal Transport Regulation Of Vesicle-mediated Transport Endosome To Lysosome Transport Cytoplasmic Transport Visual Learning Membrane Organization Visual Behavior Protein Targeting To Lysosome Protein Localization To Lysosome Associative Learning Cellular Copper Ion Homeostasis Membrane Protein Ectodomain Proteolysis Signaling Protein Targeting To Vacuole Copper Ion Homeostasis Cell Communication Negative Regulation Of Signaling Establishment Of Protein Localization To Vacuole Learning Transition Metal Ion Homeostasis Membrane Protein Proteolysis Regulation Of Exocytosis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Synaptic Plasticity Regulation Of Protein Catabolic Process Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Phosphorylation Neural Plate Formation Negative Regulation Of Kit Signaling Pathway Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Tau-protein Kinase Activity Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Choline O-acetyltransferase Activity See more
Tagcloud ?		cathepsin compartment degraded dissociates distributed en endocytic endosome enriched fuse golgi hep internalized leaves lysosome lysosomes multivesicular mvb mvbs prelysosomal prelysosome pulse return route routed steady trans vacuolar vacuoles	addressed adulthood allele attributable byg c57bl c57bl6 disrupted ear establishes gga1 gga3 ggas harbors homozygous hypomorphic insertional knockout lethality mutagenesis neonatal ola129sv placement redundancy ribosylation runted survive tigm true
Tagcloud (Difference) ?		cathepsin compartment degraded dissociates distributed en endocytic endosome enriched fuse golgi hep internalized leaves lysosome lysosomes multivesicular mvb mvbs prelysosomal prelysosome pulse return route routed steady trans vacuolar vacuoles	addressed adulthood allele attributable byg c57bl c57bl6 disrupted ear establishes gga1 gga3 ggas harbors homozygous hypomorphic insertional knockout lethality mutagenesis neonatal ola129sv placement redundancy ribosylation runted survive tigm true
Tagcloud (Intersection) ?