M6PR

Name	mannose-6-phosphate receptor, cation dependent
Structure
Novel Interactors	1 novel interactors: TMPRSS15
Interactors	12 interactors: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Protein Transporter Activity Retromer Complex Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Glycosphingolipid Catabolic Process
Pathways	Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Glycosphingolipid catabolism
Drugs	Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
GWAS	Sjögren's syndrome ( 28076899 ) Total cholesterol levels ( 30275531 ) Type 1 diabetes ( 34127860 )
Entrez ID	4074
HPRD ID	01106
Ensembl ID	ENSG00000003056
Uniprot IDs	F5GX30 P20645
PDB IDs	1JUQ
GO Terms Enriched among Interactors ?	Endosome Membrane Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Endosome Trans-Golgi Network Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Macrophage Activation Golgi Vesicle Transport Small GTPase Binding Leading Edge Cell Differentiation Protein Localization To Membrane Cellular Response To Anisomycin Juxtaglomerular Apparatus Development Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Triglyceride Storage