M6PR and GIMAP5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		M6PR	GIMAP5
Description		mannose-6-phosphate receptor, cation dependent	GTPase, IMAP family member 5
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane Multivesicular Body Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Protein Transporter Activity Retromer Complex Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Glycosphingolipid Catabolic Process
Pathways		Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Glycosphingolipid catabolism
Drugs		Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS		Sjögren's syndrome ( 28076899) Total cholesterol levels ( 30275531) Type 1 diabetes ( 34127860)
Interacting Genes		12 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4	68 interacting genes: ADGRG3 APP AQP3 AQP6 ARL13B BTNL9 CD33 CD53 CLDN7 CREB3L1 CYB561 CYBRD1 DKK4 EBP EDA EDA2R ELOVL4 EMP1 ERGIC3 EVI2B FAM174A FAM209A FAM210B FATE1 FCER1G GJA8 GJB3 GORAB GPR42 GRAMD2B IFNGR2 JAGN1 KASH5 KIR3DL3 LAYN LDLRAD1 LSMEM2 M6PR MGST2 MGST3 MILR1 MS4A14 PDZK1IP1 PTGES RETREG3 RNASEK RNF19B SCN3B SHISAL1 SLC10A1 SLC10A6 SLC35H1 SMIM3 SPACA1 STOM STX1A STX2 STX4 SYT1 TM4SF18 TM4SF19 TMEM31 TMX1 TMX2 TNFRSF19 TSPAN18 ZER1 ZFYVE27
Entrez ID		4074	55340
HPRD ID		01106	16280
Ensembl ID		ENSG00000003056	ENSG00000196329
Uniprot IDs		F5GX30 P20645	A0A090N8P9 Q96F15
PDB IDs		1JUQ	6Z3E
Enriched GO Terms of Interacting Partners?		Endosome Membrane Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Endosome Trans-Golgi Network Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Protein Localization To Cell Periphery Macrophage Activation Golgi Vesicle Transport Small GTPase Binding Leading Edge Cell Differentiation Protein Localization To Membrane Cellular Response To Anisomycin Juxtaglomerular Apparatus Development Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Triglyceride Storage	Membrane Protein Binding Exocytosis Plasma Membrane Endoplasmic Reticulum Membrane Secretion By Cell Identical Protein Binding Ascorbate Homeostasis Secretion Positive Regulation Of Regulated Secretory Pathway Regulated Exocytosis Glutathione Peroxidase Activity Transmembrane Monodehydroascorbate Reductase Activity Endomembrane System Vesicle Docking Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site SNARE Binding Tertiary Granule Membrane Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Vesicle-mediated Transport Glutathione Transferase Activity Cornified Envelope Assembly Endoplasmic Reticulum Organelle Localization By Membrane Tethering Calcium-ion Regulated Exocytosis Specific Granule Membrane Positive Regulation Of Exocytosis Renal Water Transport Chromaffin Granule Membrane Membrane Docking SNAP Receptor Activity Disulfide Oxidoreductase Activity Vesicle Fusion Glutathione Binding Icosanoid Biosynthetic Process Tumor Necrosis Factor Receptor Activity Nuclear Envelope Lumen SNARE Complex Organelle Membrane Fusion Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly
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