CSK and GSN

Number of citations of the paper that reports this interaction (PMID 10210201)
9

Data Source:
HPRD (in vitro, in vivo)

		CSK	GSN
Gene Name		c-src tyrosine kinase	gelsolin
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome	Ruffle Extracellular Region Cytosol Focal Adhesion Actin Cytoskeleton Lamellipodium Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Identical Protein Binding Proline-rich Region Binding	Actin Binding Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Cytokine Production Morphogenesis Of An Epithelium Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Cell Differentiation Platelet Activation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Aging Oligodendrocyte Development Vesicle-mediated Transport Actin Filament Polymerization Regulation Of Cell Adhesion Tissue Regeneration Actin Nucleation Response To Ethanol Phosphatidylinositol-mediated Signaling Actin Filament Severing Barbed-end Actin Filament Capping Response To Folic Acid Cilium Morphogenesis Cellular Response To Cadmium Ion
Pathways		Costimulation by the CD28 family GAB1 signalosome Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFR TCR signaling Signaling by EGFR in Cancer PD-1 signaling Platelet activation, signaling and aggregation Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Amyloids Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins
Drugs		Staurosporine
Diseases
GWAS		Blood pressure ( 21909110) Caffeine consumption ( 21490707) Diastolic blood pressure ( 19430479 19430483) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		46 interactors: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDH5 CREBBP DAB2 DOK1 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 ZAP70 ZNF212	23 interactors: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CLIC5 CSK FHIT FN1 LIMK2 PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1
Entrez ID		1445	2934
HPRD ID		00496	00674
Ensembl ID		ENSG00000103653	ENSG00000148180
Uniprot IDs		A8K3B6 B2R6Q4 P41240	B7Z4U6 B7Z5V1 F5H1A8 P06396
PDB IDs		1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ	1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5
Enriched GO Terms of Interacting Partners?		Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cell Adhesion Protein Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Regulation Of Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Response To Peptide Hormone Immune System Process Regulation Of Intracellular Signal Transduction Response To Peptide Positive Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Intracellular Signal Transduction Leukocyte Migration Positive Regulation Of Cellular Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Response To Wounding Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Wound Healing Negative Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune Response Innate Immune Response	Platelet Activation Blood Coagulation Hemostasis Cell Junction Assembly Response To Wounding Regulation Of Body Fluid Levels Wound Healing Adherens Junction Organization Movement Of Cell Or Subcellular Component Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Response To Stimulus Response To Stress Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Cell Morphogenesis Regulation Of Kinase Activity Cell Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cell Differentiation Cellular Component Assembly Cell Projection Organization Signaling Anatomical Structure Development Generation Of Neurons Platelet Aggregation Cell Communication Positive Regulation Of Protein Metabolic Process Locomotion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Nervous System Development Developmental Process Multicellular Organismal Development Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neuron Differentiation System Development Regulation Of Cellular Component Organization Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections	amyloidogenic amyloidosis autosomal contractility counter crossbreeding dermatological disturbed dominantly folding furin g2 g654a gelsolin generates hampered hereditary inherited mt1 nanobodies nanobody nb11 ophthalmological proteases proteolysis proteolytic rendering secreting shield
Tagcloud (Difference) ?		associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections	amyloidogenic amyloidosis autosomal contractility counter crossbreeding dermatological disturbed dominantly folding furin g2 g654a gelsolin generates hampered hereditary inherited mt1 nanobodies nanobody nb11 ophthalmological proteases proteolysis proteolytic rendering secreting shield
Tagcloud (Intersection) ?