CSK and FGR

Number of citations of the paper that reports this interaction (PubMedID 7515063)
0

Data Source:
HPRD (in vivo)

		CSK	FGR
Description		C-terminal Src kinase	FGR proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Extracellular Exosome	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Aggresome Ruffle Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Protein Kinase A Catalytic Subunit Binding Identical Protein Binding Metal Ion Binding Proline-rich Region Binding Protein Tyrosine Kinase Binding	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Adaptive Immune Response Immune System Process Regulation Of Immune System Process Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance T Cell Costimulation Negative Regulation Of Interleukin-6 Production Adherens Junction Organization Intracellular Signal Transduction Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Regulation Of Multicellular Organismal Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus	Positive Regulation Of Cytokine Production Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Response To Virus Peptidyl-tyrosine Phosphorylation Cell Differentiation Bone Mineralization Positive Regulation Of Cell Migration Negative Regulation Of Natural Killer Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Skeletal System Morphogenesis Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains Integrin signaling Co-inhibition by PD-1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOH GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Negative regulation of FLT3	FCGR activation Platelet sensitization by LDL Neutrophil degranulation FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs		Dasatinib Staurosporine TG-100801 Fostamatinib	Dasatinib Fostamatinib Zanubrutinib
Diseases
GWAS		Blood pressure ( 21909110) Blood protein levels ( 30072576) Body mass index and systole blood pressure (pairwise) ( 33619380) Caffeine consumption ( 21490707) Coffee consumption ( 31959922) Diastolic blood pressure ( 19430483 26390057 19430479) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Hypertension ( 31513605) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Serum albumin levels ( 29403010) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Systolic blood pressure ( 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)	Body mass index ( 28892062) Systolic blood pressure ( 30224653)
Interacting Genes		51 interacting genes: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDC45 CDH5 CREBBP DAB2 DOK1 DOK2 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KANK4 KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PDPK1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 UBE2I ZAP70 ZNF212	30 interacting genes: AR ARRB1 CBL CCR3 CSK DAB2 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG HCLS1 IKBKG INPP5D KHDRBS1 KIT MET NR1I2 PTK2 SKAP2 SLAMF1 SMURF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ
Entrez ID		1445	2268
HPRD ID		00496	01288
Ensembl ID		ENSG00000103653	ENSG00000000938
Uniprot IDs		A8K3B6 B2R6Q4 P41240	P09769 P78453
PDB IDs		1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ	7JT9 7UY0 7UY3
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Activation Of Immune Response Fc Receptor Signaling Pathway Focal Adhesion Positive Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Signaling Regulation Of Cell Communication Fc Receptor Mediated Stimulatory Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Protein Tyrosine Kinase Activity Intracellular Signal Transduction Protein Phosphorylation Immune System Process Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade T Cell Costimulation Positive Regulation Of Immune Response Regulation Of Programmed Cell Death Phosphorylation Anchoring Junction Regulation Of Immune Response Positive Regulation Of Immune System Process Membrane Raft Positive Regulation Of Multicellular Organismal Process Plasma Membrane SH2 Domain Binding Regulation Of Immune System Process Protein Kinase Activity Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Signal Complex Assembly Phosphotyrosine Residue Binding Negative Regulation Of Cell Communication	Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death SH2 Domain Binding Negative Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process ERBB2 Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Regulation Of ERK1 And ERK2 Cascade Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Immune System Process Plasma Membrane Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Gene Expression Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Kinase Activity Negative Regulation Of Apoptotic Process
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