CSK and TLR3

Number of citations of the paper that reports this interaction (PMID 16858407)
49

Data Source:
HPRD (in vivo)

		CSK	TLR3
Gene Name		c-src tyrosine kinase	toll-like receptor 3
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Endolysosome Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Identical Protein Binding Proline-rich Region Binding	Double-stranded RNA Binding Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cytokine Production Morphogenesis Of An Epithelium Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Cell Differentiation Platelet Activation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus	Toll-like Receptor Signaling Pathway Microglial Cell Activation Involved In Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Hyperosmotic Response Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation Male Gonad Development Detection Of Virus Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Type III Interferon Production Cellular Response To Interferon-beta TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Drug Positive Regulation Of NF-kappaB Import Into Nucleus Defense Response To Bacterium Positive Regulation Of Apoptotic Process Response To Exogenous DsRNA Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Chemokine Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Cellular Response To Mechanical Stimulus Cellular Response To Interferon-gamma Cellular Response To Exogenous DsRNA Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway
Pathways		Costimulation by the CD28 family GAB1 signalosome Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFR TCR signaling Signaling by EGFR in Cancer PD-1 signaling Platelet activation, signaling and aggregation Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death Innate Immune System
Drugs		Staurosporine
Diseases
GWAS		Blood pressure ( 21909110) Caffeine consumption ( 21490707) Diastolic blood pressure ( 19430479 19430483) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Breast size ( 22747683)
Protein-Protein Interactions		46 interactors: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDH5 CREBBP DAB2 DOK1 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 ZAP70 ZNF212	8 interactors: CD14 CSK MAP2K6 MYD88 RNF216 TICAM1 TICAM2 TRAF6
Entrez ID		1445	7098
HPRD ID		00496	04324
Ensembl ID		ENSG00000103653
Uniprot IDs		A8K3B6 B2R6Q4 P41240	E6Y0F1 O15455
PDB IDs		1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ	1ZIW 2A0Z 3ULU 3ULV
Enriched GO Terms of Interacting Partners?		Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cell Adhesion Protein Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Regulation Of Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Response To Peptide Hormone Immune System Process Regulation Of Intracellular Signal Transduction Response To Peptide Positive Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Intracellular Signal Transduction Leukocyte Migration Positive Regulation Of Cellular Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Response To Wounding Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Wound Healing Negative Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune Response Innate Immune Response	Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Positive Regulation Of Immune Response Regulation Of Immune System Process Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Response Positive Regulation Of Immune System Process I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Interleukin-6 Production MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Cellular Response To Lipid Cellular Response To Organic Substance Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Chemokine Production Immune System Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 9 Signaling Pathway Response To Organic Substance Positive Regulation Of Cytokine Biosynthetic Process Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Cell Activation
Tagcloud ?		associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections	addressed adoptive autoimmune cytoskeletal defective deletes detects displaying drive dx5 ex immunotherapies intermediates lymphocyte marginal mobilization myd88 polyic retained spleen subsets t1d toll traced trif triggers unexpectedly zone
Tagcloud (Difference) ?		associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections	addressed adoptive autoimmune cytoskeletal defective deletes detects displaying drive dx5 ex immunotherapies intermediates lymphocyte marginal mobilization myd88 polyic retained spleen subsets t1d toll traced trif triggers unexpectedly zone
Tagcloud (Intersection) ?