CSK and DAB2

Number of citations of the paper that reports this interaction (PMID 12473651)
18

Data Source:
HPRD (in vitro, in vivo)

		CSK	DAB2
Gene Name		c-src tyrosine kinase	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome	Nucleolus Lysosomal Membrane Plasma Membrane Coated Pit Focal Adhesion Apical Plasma Membrane Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle Transforming Growth Factor Beta Receptor Homodimeric Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Identical Protein Binding Proline-rich Region Binding	Integrin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding
	Biological Process	Regulation Of Cytokine Production Morphogenesis Of An Epithelium Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Cell Differentiation Platelet Activation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus	Cell Morphogenesis Involved In Differentiation In Utero Embryonic Development Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Pinocytosis Apoptotic Process Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Endoderm Development Excretion Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Transport Wnt Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Clathrin Coat Assembly Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Costimulation by the CD28 family GAB1 signalosome Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFR TCR signaling Signaling by EGFR in Cancer PD-1 signaling Platelet activation, signaling and aggregation Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Formation of annular gap junctions Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking
Drugs		Staurosporine
Diseases
GWAS		Blood pressure ( 21909110) Caffeine consumption ( 21490707) Diastolic blood pressure ( 19430479 19430483) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Chronic kidney disease ( 20383146) Pancreatic cancer ( 22158540) Urate levels ( 23263486)
Protein-Protein Interactions		46 interactors: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDH5 CREBBP DAB2 DOK1 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 ZAP70 ZNF212	37 interactors: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 DYT10 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SMAD2 SMAD3 SMURF2 SRC TGFBR1 TGFBR2
Entrez ID		1445	1601
HPRD ID		00496	03139
Ensembl ID		ENSG00000103653	ENSG00000153071
Uniprot IDs		A8K3B6 B2R6Q4 P41240	B2RAW0 P98082
PDB IDs		1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ	2LSW
Enriched GO Terms of Interacting Partners?		Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cell Adhesion Protein Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Regulation Of Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Response To Peptide Hormone Immune System Process Regulation Of Intracellular Signal Transduction Response To Peptide Positive Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Intracellular Signal Transduction Leukocyte Migration Positive Regulation Of Cellular Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Response To Wounding Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Wound Healing Negative Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune Response Innate Immune Response	Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Signal Transduction Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signal Transduction Signaling Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Developmental Process Positive Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Anatomical Structure Morphogenesis Multicellular Organismal Development Wound Healing Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Nervous System Development Embryonic Morphogenesis System Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Immune System Process Anatomical Structure Development Platelet Activation
Tagcloud ?		associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections	associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Difference) ?		associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections	associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Intersection) ?