CSK and MAPK15

Number of citations of the paper that reports this interaction (PubMedID 11875070)
0

Data Source:
HPRD (in vivo)

		CSK	MAPK15
Description		C-terminal Src kinase	mitogen-activated protein kinase 15
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Extracellular Exosome	Extracellular Region Nucleus Cytoplasm Autophagosome Golgi Apparatus Centriole Spindle Cytoskeleton Cell-cell Junction Bicellular Tight Junction Axoneme Cytoplasmic Vesicle Ciliary Basal Body Cell Projection Anchoring Junction Meiotic Spindle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Protein Kinase A Catalytic Subunit Binding Identical Protein Binding Metal Ion Binding Proline-rich Region Binding Protein Tyrosine Kinase Binding	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Protein Serine Kinase Activity
	Biological Process	Adaptive Immune Response Immune System Process Regulation Of Immune System Process Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance T Cell Costimulation Negative Regulation Of Interleukin-6 Production Adherens Junction Organization Intracellular Signal Transduction Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Regulation Of Multicellular Organismal Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus	MAPK Cascade Regulation Of COPII Vesicle Coating DNA Damage Response Endoplasmic Reticulum Organization Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Negative Regulation Of Cell Migration Positive Regulation Of Telomere Maintenance Cellular Response To Stress Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Dopamine Uptake Regulation Of Cilium Assembly Protein Localization To Ciliary Transition Zone Positive Regulation Of Metaphase/anaphase Transition Of Meiosis I Positive Regulation Of Spindle Assembly
Pathways		GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains Integrin signaling Co-inhibition by PD-1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOH GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Negative regulation of FLT3
Drugs		Dasatinib Staurosporine TG-100801 Fostamatinib	Acetylsalicylic acid Minocycline Colforsin Fostamatinib
Diseases
GWAS		Blood pressure ( 21909110) Blood protein levels ( 30072576) Body mass index and systole blood pressure (pairwise) ( 33619380) Caffeine consumption ( 21490707) Coffee consumption ( 31959922) Diastolic blood pressure ( 19430483 26390057 19430479) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Hypertension ( 31513605) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Serum albumin levels ( 29403010) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Systolic blood pressure ( 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)	Obesity-related traits ( 23251661)
Interacting Genes		51 interacting genes: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDC45 CDH5 CREBBP DAB2 DOK1 DOK2 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KANK4 KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PDPK1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 UBE2I ZAP70 ZNF212	8 interacting genes: CLIC3 CSK GABARAP GABARAPL1 MBP NR3C1 SRC TGFB1I1
Entrez ID		1445	225689
HPRD ID		00496	16867
Ensembl ID		ENSG00000103653	ENSG00000181085
Uniprot IDs		A8K3B6 B2R6Q4 P41240	Q8TD08
PDB IDs		1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Activation Of Immune Response Fc Receptor Signaling Pathway Focal Adhesion Positive Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Signaling Regulation Of Cell Communication Fc Receptor Mediated Stimulatory Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Protein Tyrosine Kinase Activity Intracellular Signal Transduction Protein Phosphorylation Immune System Process Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade T Cell Costimulation Positive Regulation Of Immune Response Regulation Of Programmed Cell Death Phosphorylation Anchoring Junction Regulation Of Immune Response Positive Regulation Of Immune System Process Membrane Raft Positive Regulation Of Multicellular Organismal Process Plasma Membrane SH2 Domain Binding Regulation Of Immune System Process Protein Kinase Activity Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Signal Complex Assembly Phosphotyrosine Residue Binding Negative Regulation Of Cell Communication	Positive Regulation Of Proteolysis Cellular Response To Nutrient Levels Cellular Response To Nitrogen Starvation Autophagosome Assembly Glial Cell Differentiation Positive Regulation Of Protein Metabolic Process Autophagosome Organization Phosphatidylethanolamine Binding Regulation Of Proteolysis GABA Receptor Binding Positive Regulation Of Multicellular Organismal Process Macroautophagy Response To Nutrient Levels Vacuole Organization Signal Transduction Regulation Of Bone Resorption T Cell Costimulation Regulation Of Bone Remodeling Oligodendrocyte Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Beta-tubulin Binding Autophagosome Maturation Negative Regulation Of Cell Adhesion Nuclear Glucocorticoid Receptor Activity Cytoskeleton Chemical Synaptic Transmission Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Metalloendopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Autophagy Mitophagy Autophagosome Membrane Cellular Response To Hormone Stimulus Cytosol Morphogenesis Of An Epithelium Trans-synaptic Signaling Response To Transforming Growth Factor Beta Synaptic Signaling Autophagy Of Mitochondrion Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Tissue Remodeling Autophagosome Cellular Response To Steroid Hormone Stimulus TOR Signaling Positive Regulation Of TOR Signaling Tissue Morphogenesis Protein-disulfide Reductase (glutathione) Activity
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