ANKRA2 and SAMD4A

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ANKRA2	SAMD4A
Name		ankyrin repeat family A member 2	sterile alpha motif domain containing 4A
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Protein-containing Complex 3M Complex	P-body Fibrillar Center Cytoplasm Cytosol Cell Junction Dendrite Cell Projection Neuron Projection Synapse
	Molecular Function	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Low-density Lipoprotein Particle Receptor Binding	RNA Binding MRNA Binding Protein Binding Translation Repressor Activity
	Biological Process	Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly	Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation Negative Regulation Of Translation Regulation Of MRNA Stability Positive Regulation Of Translation
GWAS		Monobrow thickness ( 26926045 )	Aspartate aminotransferase levels ( 33547301 ) Cortical amyloid beta load ( 29860282 ) Creatine kinase levels ( 29403010 ) Hand grip strength ( 29313844 ) Height ( 31562340 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Plateletcrit ( 27863252 ) Pulse pressure ( 30224653 ) Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775 ) Tea consumption ( 31046077 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		13 interacting genes: ABL1 APP CDKN2A HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX7 SAMD4A TSHZ3	14 interacting genes: AKAP8L ANKRA2 BAG4 GOLGA2 HSF2BP MEOX2 MTUS2 NFKBID NUTM1 PRDM6 PRKAB2 SNCA TBC1D21 YWHAG
Entrez ID		57763	23034
HPRD ID		12044	10209
Ensembl ID		ENSG00000164331	ENSG00000020577
Uniprot IDs		Q9H9E1	G3V2R1 Q8WW19 Q9UPU9
PDB IDs		3SO8 3V2O 3V2X 3V31 4LG6 4QQI 8CXG 8CXH 8CXI	8OIK
GO Terms Enriched among Interactors		Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity B Cell Differentiation Negative Regulation Of Metabolic Process Protein Kinase C Binding Mononuclear Cell Differentiation Leukocyte Activation Cell Activation Regulation Of Myotube Differentiation Histone Deacetylase Complex Regulation Of Cell Differentiation Leukocyte Differentiation Regulation Of Cell Migration Involved In Sprouting Angiogenesis DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Mitochondrial Depolarization B Cell Activation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Developmental Process Lymphocyte Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type II Interferon Production Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Macromolecule Metabolic Process Lymphocyte Differentiation Negative Regulation Of Long-term Synaptic Potentiation Regulation Of RNA Metabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Striated Muscle Cell Differentiation Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Catecholamine Stimulus Negative Regulation Of Myotube Differentiation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Type II Interferon Production Regulation Of Multicellular Organismal Process Response To Catecholamine Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Superoxide Anion Generation SUMO Transferase Activity Regulation Of Metabolic Process Regulation Of Superoxide Anion Generation Negative Regulation Of Biosynthetic Process Endosome Lumen Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression	None