PIP5K1C and BTK

Number of citations of the paper that reports this interaction (PMID 14614850)
4

Data Source:
HPRD (in vitro, in vivo)

		PIP5K1C	BTK
Gene Name		phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	Bruton agammaglobulinemia tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Uropod Nucleus Cytosol Focal Adhesion Endomembrane System Ruffle Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Mast Cell Granule Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Talin Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Cytoskeletal Anchoring At Plasma Membrane Axon Guidance Synaptic Vesicle Exocytosis Single Organismal Cell-cell Adhesion Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Synaptic Vesicle Endocytosis Platelet Aggregation Clathrin-mediated Endocytosis	Toll-like Receptor Signaling Pathway Adaptive Immune Response Histamine Secretion By Mast Cell Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Mesoderm Development Calcium-mediated Signaling Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway B Cell Activation Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of B Cell Differentiation Cell Maturation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway
Pathways		Synthesis of PIPs at the plasma membrane Axon guidance Metabolism of lipids and lipoproteins Semaphorin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Phospholipid metabolism PI Metabolism	Signaling by the B Cell Receptor (BCR) DAP12 interactions Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MyD88:Mal cascade initiated on plasma membrane FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System
Drugs			Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AP1B1 AP2B1 ARF6 BTK CDH1 CDK5 HDHD2 LRP2 TLN2	64 interactors: ABL1 APP ARHGAP17 ARID3A ARRB1 BCL2L11 BLNK BMX CAV1 CBL CD19 CMTM3 DAPP1 EWSR1 FAS FASLG FYN GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MYD88 PIK3AP1 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2
Entrez ID		23396	695
HPRD ID		05834	02248
Ensembl ID		ENSG00000186111	ENSG00000010671
Uniprot IDs		O60331	Q06187 Q5JY90
PDB IDs		3H1Z 3H85	1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3
Enriched GO Terms of Interacting Partners?		Cellular Protein Localization Cellular Localization Vesicle-mediated Transport Protein Localization Regulation Of Defense Response To Virus By Virus Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Of Protein Localization Regulation Of Dendritic Spine Development Regulated Secretory Pathway Apoptotic Process Programmed Cell Death Regulation Of B Cell Cytokine Production Synapse Assembly Cell Death Death Regulation Of Defense Response To Virus Cell Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Forebrain Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cell Projection Organization Cell Adhesion Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Dendrite Development Nervous System Development Cellular Response To Molecule Of Fungal Origin Cell-cell Junction Assembly Regulation Of Immune System Process Negative Regulation Of Synaptic Plasticity Protein Transport Response To Molecule Of Fungal Origin Endocytosis Intracellular Transport Positive Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Protein Localization Generation Of Neurons Serine Phosphorylation Of STAT3 Protein Cellular Response To Indole-3-methanol Regulation Of Cell Differentiation Synapse Organization Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Serine Phosphorylation Of STAT Protein Neurogenesis Brain Development Cell Junction Assembly Activation Of Anaphase-promoting Complex Activity Negative Regulation Of Protein Export From Nucleus	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Immune System Process Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune Response Cellular Response To Stimulus Blood Coagulation Hemostasis Cell Activation Response To Stress Defense Response Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Wound Healing Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Intracellular Signal Transduction Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Stimulus Fc Receptor Signaling Pathway Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Response To Organic Substance Phosphorylation Cellular Response To Organic Substance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Metabolic Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytokine Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Leukocyte Activation Protein Autophosphorylation
Tagcloud ?		ca chelator contents differentiate differentiation disrupted evoke ezh2 hmscs homolog intracellular knockdown knocking lineages mesenchymal modulates neurological neuron neuronal plc proliferating renewal repressing silenced suppress turn zeste	adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction
Tagcloud (Difference) ?		ca chelator contents differentiate differentiation disrupted evoke ezh2 hmscs homolog intracellular knockdown knocking lineages mesenchymal modulates neurological neuron neuronal plc proliferating renewal repressing silenced suppress turn zeste	adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction
Tagcloud (Intersection) ?