PIP5K1C and LRP2

Number of citations of the paper that reports this interaction (PMID 10827173)
91

Data Source:
HPRD (in vitro, two hybrid)

		PIP5K1C	LRP2
Gene Name		phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	low density lipoprotein receptor-related protein 2
Image
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Uropod Nucleus Cytosol Focal Adhesion Endomembrane System Ruffle Membrane	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Talin Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Cytoskeletal Anchoring At Plasma Membrane Axon Guidance Synaptic Vesicle Exocytosis Single Organismal Cell-cell Adhesion Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Synaptic Vesicle Endocytosis Platelet Aggregation Clathrin-mediated Endocytosis	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process
Pathways		Synthesis of PIPs at the plasma membrane Axon guidance Metabolism of lipids and lipoproteins Semaphorin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Phospholipid metabolism PI Metabolism	Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs			Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS			Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		9 interactors: AP1B1 AP2B1 ARF6 BTK CDH1 CDK5 HDHD2 LRP2 TLN2	48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		23396	4036
HPRD ID		05834	02509
Ensembl ID		ENSG00000186111	ENSG00000081479
Uniprot IDs		O60331	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		3H1Z 3H85	2M0P
Enriched GO Terms of Interacting Partners?		Cellular Protein Localization Cellular Localization Vesicle-mediated Transport Protein Localization Regulation Of Defense Response To Virus By Virus Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Of Protein Localization Regulation Of Dendritic Spine Development Regulated Secretory Pathway Apoptotic Process Programmed Cell Death Regulation Of B Cell Cytokine Production Synapse Assembly Cell Death Death Regulation Of Defense Response To Virus Cell Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Forebrain Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cell Projection Organization Cell Adhesion Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Dendrite Development Nervous System Development Cellular Response To Molecule Of Fungal Origin Cell-cell Junction Assembly Regulation Of Immune System Process Negative Regulation Of Synaptic Plasticity Protein Transport Response To Molecule Of Fungal Origin Endocytosis Intracellular Transport Positive Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Protein Localization Generation Of Neurons Serine Phosphorylation Of STAT3 Protein Cellular Response To Indole-3-methanol Regulation Of Cell Differentiation Synapse Organization Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Serine Phosphorylation Of STAT Protein Neurogenesis Brain Development Cell Junction Assembly Activation Of Anaphase-promoting Complex Activity Negative Regulation Of Protein Export From Nucleus	Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation
Tagcloud ?		ca chelator contents differentiate differentiation disrupted evoke ezh2 hmscs homolog intracellular knockdown knocking lineages mesenchymal modulates neurological neuron neuronal plc proliferating renewal repressing silenced suppress turn zeste	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Difference) ?		ca chelator contents differentiate differentiation disrupted evoke ezh2 hmscs homolog intracellular knockdown knocking lineages mesenchymal modulates neurological neuron neuronal plc proliferating renewal repressing silenced suppress turn zeste	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Intersection) ?