PIP5K1C and SMURF1

Number of citations of the paper that reports this interaction (PubMedID 28581524)
0

Data Source:
BioGRID (pull down, imaging technique)

		PIP5K1C	SMURF1
Description		phosphatidylinositol-4-phosphate 5-kinase type 1 gamma	SMAD specific E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Phagocytic Cup Uropod Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion Endosome Membrane Endomembrane System Membrane Ruffle Membrane Cell Projection Anchoring Junction Presynapse	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity Transferase Activity Phosphatidylinositol Kinase Activity	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Phospholipid Binding Transferase Activity SMAD Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding Activin Receptor Binding
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Exocytosis Endocytosis Phagocytosis Chemotaxis Cell Adhesion Synaptic Vesicle Exocytosis Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Synaptic Vesicle Endocytosis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Organization Clathrin-dependent Endocytosis Cell-cell Adhesion	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Export From Nucleus Ectoderm Development Protein Ubiquitination Cell Differentiation BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Receptor Catabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Axon Extension Wnt Signaling Pathway, Planar Cell Polarity Pathway Engulfment Of Target By Autophagosome Substrate Localization To Autophagosome Protein Targeting To Vacuole Involved In Autophagy Protein Localization To Plasma Membrane Positive Regulation Of Dendrite Extension Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Signaling by BMP Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Asymmetric localization of PCP proteins Hedgehog 'on' state Hedgehog 'on' state Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Lethal congenital contractural syndrome (LCCS)
GWAS			Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 23128233 28067908) Lack of premeditation ( 30718321) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Ulcerative colitis ( 20228798 28067908)
Interacting Genes		20 interacting genes: AKT1 AKT2 AP1B1 AP2B1 ARF6 BTK CDH1 CDK1 CDK5 HDHD2 ITGB1 LAPTM4B LRP2 NEDD4 PKD1 SMURF1 SNCA SRC TLN1 TLN2	188 interacting genes: ADRM1 ANAPC5 ANKRD13A ANKRD13D ANKRD50 ANKS4B ANXA6 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASCC2 ASH2L ATXN3 AVEN AXIN1 BMPR2 BTK BTRC C9orf78 CALCOCO1 CCDC69 CCM2 CDC40 CDK14 CDKL1 CSNK1D CSNK2A2 CTNNB1 CTNND1 CTTN CUEDC1 CUL5 CXXC1 DDX54 DNAJC7 DUSP13B DVL2 ECSIT ELOF1 ELP3 ENTR1 EPHA1 EPN1 ETV6 FAF2 FBXL15 FBXO3 FBXO30 FCHO1 FES FGF12 FGR FKBP3 FSCN1 FZR1 GNG11 GRIPAP1 GRK3 HDGFL3 HIP1 HOMER2 ILRUN IMPACT ING2 INPP5B IRAK2 ITGB1BP1 ITK JUNB KRT36 LATS1 LCK LHX9 LIMS1 LMNA LONRF3 MAP3K10 MAP3K2 MAP3K3 MAP3K9 MAP4K5 MARK2 MATK MINDY3 MSN NAA16 NDFIP2 NEDD8 NEK2 ODF2 OTUD6B OXSR1 PADI4 PAK1 PAK1IP1 PDGFRA PDLIM7 PICALM PIP5K1C PLEKHO1 POLR2A PRKCA PRKCG PRKCI PRR16 PSMD4 PSME3 PTEN PWP1 RABEP1 RAD23A RASD2 RBCK1 RHOA RHOB RHPN2 RIOK3 RIPK2 RIT1 RNF11 RNF114 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SCYL1 SENP8 SF3A1 SKIC8 SLAIN2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SQSTM1 SRSF4 SRSF5 STK31 STK35 STRAP STUB1 TAB1 TAOK3 TAPT1 TBK1 TLN1 TNIK TNIP2 TNK2 TNNT1 TOM1 TOM1L2 TRAF4 TRIP10 TTC17 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2K UBE2L3 UBE2M UBE2V1 UBQLN1 UBQLN2 UBTF UBXN1 UBXN6 UBXN7 USP45 USP9X WEE1 WFS1 XPO1 ZFAND5
Entrez ID		23396	57154
HPRD ID		05834	06902
Ensembl ID		ENSG00000186111	ENSG00000198742
Uniprot IDs		O60331	Q9HCE7
PDB IDs		2G35 3H1Z 3H85	2LAZ 2LB0 2LB1 2LTX 3PYC
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Localization Positive Regulation Of Transport Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Regulation Of Protein Localization Cell Junction Organization Regulation Of Transport Intracellular Protein Transport Membrane Synaptic Vesicle Endocytosis Intracellular Protein Localization Regulation Of Protein Catabolic Process Presynaptic Endocytosis Plasma Membrane Vesicle-mediated Transport Cellular Localization Regulation Of Protein Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Endocytosis Regulation Of Protein Localization To Cell Periphery Regulation Of Synapse Organization Protein Localization To Membrane Receptor Internalization Receptor Catabolic Process Regulation Of Protein Localization To Membrane Receptor-mediated Endocytosis Protein Transport Cell Cortex Phospholipase Binding Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Vesicle-mediated Transport Positive Regulation Of Catabolic Process Protein Localization To Plasma Membrane Actin Cytoskeleton Organization Positive Regulation Of Protein Localization To Membrane Cellular Component Assembly Intracellular Transport Vesicle-mediated Transport In Synapse Cell Adhesion Import Into Cell Positive Regulation Of Protein Localization To Nucleus Ruffle Membrane Ionotropic Glutamate Receptor Binding Protein Localization To Cell Periphery Actin Filament-based Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Ruffle Extracellular Exosome	Cytosol Protein Kinase Activity Modification-dependent Protein Catabolic Process Protein Modification Process Cytoplasm Proteolysis Involved In Protein Catabolic Process Kinase Activity Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Intracellular Signaling Cassette Macromolecule Catabolic Process Protein Serine Kinase Activity Proteolysis Post-translational Protein Modification Proteasomal Protein Catabolic Process ATP Binding Nucleus Regulation Of Proteasomal Protein Catabolic Process I-SMAD Binding Nucleotide Binding Macromolecule Metabolic Process Signal Transduction Regulation Of Proteolysis Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Transferase Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Nucleoplasm Protein Modification By Small Protein Conjugation Protein Phosphorylation Heteromeric SMAD Protein Complex Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Ubiquitin Binding Regulation Of Cell Communication Protein Polyubiquitination Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Protein Ubiquitination Polyubiquitin Modification-dependent Protein Binding
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