SNX17 and SELP

Number of citations: 0 (PubMedID 11237770)
Data Source: HPRD (two hybrid)

		SNX17	SELP
Name		sorting nexin 17	selectin P
Structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding	Lipopolysaccharide Binding Integrin Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Metal Ion Binding Calcium-dependent Protein Binding Oligosaccharide Binding
	Biological Process	Kidney Development Cardiac Septum Development Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Regulation Of Endocytosis Endocytic Recycling Aorta Development Coronary Vasculature Development	Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Response To Cytokine Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		None	Platelet degranulation Cell surface interactions at the vascular wall
Drugs		None	Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin Crizanlizumab
GWAS		Alcohol use disorder (total score) ( 30336701 ) Crohn's disease ( 28067908 ) High light scatter reticulocyte count ( 27863252 ) Inflammatory bowel disease ( 28067908 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Microalbuminuria ( 31511532 ) Non-oily fish consumption ( 32066663 ) Refractive error ( 32231278 ) Reticulocyte count ( 27863252 ) Reticulocyte fraction of red cells ( 27863252 ) Serum alkaline phosphatase levels ( 33339817 ) Triglyceride levels ( 34074324 32902719 32203549 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 30910378 31511532 31630189 32600054 ) Urinary sodium to potassium ratio ( 30910378 )	Activated partial thromboplastin time ( 22703881 ) Blood protein levels ( 30072576 ) Hippocampal atrophy ( 22745009 ) Inflammatory bowel disease ( 26192919 ) L-selectin levels ( 25576479 ) Late-onset Alzheimer's disease ( 27770636 ) Monocyte count ( 32888494 ) Optic disc size ( 31809533 ) Soluble levels of adhesion molecules ( 20167578 ) Total ventricular volume ( 21116278 )
Interacting Genes		16 interacting genes: ACE2 ANXA2 APP HOXC8 HRAS LDLR LRP1 LRP2 LRP8 RABAC1 RIN1 RLIM RNF128 SELP SKIL VLDLR	10 interacting genes: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN
Entrez ID		9784	6403
HPRD ID		05812	01433
Ensembl ID		ENSG00000115234	ENSG00000174175
Uniprot IDs		B4DDM3 B4DQ37 B4DTB8 Q15036	B2R785 P16109 Q5R341 Q6NUL9
PDB IDs		3FOG 3LUI 4GXB 4TKN 7RM8 9AU7	1FSB 1G1Q 1G1R 1G1S 1HES
GO Terms Enriched among Interactors		Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Endocytosis Apolipoprotein Binding Very-low-density Lipoprotein Particle Receptor Activity Import Into Cell Clathrin-coated Pit Positive Regulation Of Lysosomal Protein Catabolic Process Cargo Receptor Activity Receptor Complex Vesicle-mediated Transport Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Receptor-mediated Endocytosis Reelin Receptor Activity Diterpenoid Metabolic Process Calcium-dependent Protein Binding Regulation Of Protein Catabolic Process Calcium Ion Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Catabolic Process Terpenoid Metabolic Process Amyloid-beta Clearance Isoprenoid Metabolic Process Astrocyte Activation Involved In Immune Response Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Early Endosome Plasma Membrane Amyloid-beta Clearance By Cellular Catabolic Process Ventral Spinal Cord Development Regulation Of Neurogenesis Artery Morphogenesis Clathrin Heavy Chain Binding Reelin-mediated Signaling Pathway Regulation Of Nervous System Development Membrane Plasma Membrane Protein Complex Low-density Lipoprotein Particle Amyloid-beta Binding Positive Regulation Of Dendrite Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Heparan Sulfate Proteoglycan Binding Regulation Of Amyloid Fibril Formation Astrocyte Activation Neuron Projection Morphogenesis Regulation Of Low-density Lipoprotein Particle Clearance	Localization Within Membrane Uropod Fibrinolysis Cell Migration Cell Adhesion Cellular Localization Receptor-mediated Endocytosis Establishment Of Localization In Cell Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Cell Motility Intracellular Protein Localization IgE Receptor Activity Vesicle-mediated Transport Leukocyte Migration Cell Activation Cell Surface Regulation Of Platelet Activation Leukocyte Cell-cell Adhesion Plasma Membrane Raft Immunological Synapse Intracellular Protein Transport Establishment Of Natural Killer Cell Polarity Negative Regulation Of Transforming Growth Factor Beta3 Production B Cell Receptor Transport Into Membrane Raft Chemokine Receptor Transport Out Of Membrane Raft Membrane Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Receptor Internalization Protein Localization To Membrane Regulation Of Hemostasis Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Type I Hypersensitivity External Side Of Plasma Membrane Fc-epsilon Receptor I Complex Lewis X Epitope Biosynthetic Process Leukocyte Adhesive Activation Terminal Web Assembly Early Endosome Endocytic Recycling Glomerular Parietal Epithelial Cell Differentiation Blood Coagulation Regulation Of Immune System Process Interphotoreceptor Matrix Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity