SNX17

Name	sorting nexin 17
Structure
Novel Interactors	3 novel interactors: KCNG3 PEX10 RHOB
Interactors	16 interactors: ACE2 ANXA2 APP HOXC8 HRAS LDLR LRP1 LRP2 LRP8 RABAC1 RIN1 RLIM RNF128 SELP SKIL VLDLR
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Kidney Development Cardiac Septum Development Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Regulation Of Endocytosis Endocytic Recycling Aorta Development Coronary Vasculature Development
GWAS	Alcohol use disorder (total score) ( 30336701 ) Crohn's disease ( 28067908 ) High light scatter reticulocyte count ( 27863252 ) Inflammatory bowel disease ( 28067908 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Microalbuminuria ( 31511532 ) Non-oily fish consumption ( 32066663 ) Refractive error ( 32231278 ) Reticulocyte count ( 27863252 ) Reticulocyte fraction of red cells ( 27863252 ) Serum alkaline phosphatase levels ( 33339817 ) Triglyceride levels ( 34074324 32902719 32203549 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 30910378 31511532 31630189 32600054 ) Urinary sodium to potassium ratio ( 30910378 )
Entrez ID	9784
HPRD ID	05812
Ensembl ID	ENSG00000115234
Uniprot IDs	B4DDM3 B4DQ37 B4DTB8 Q15036
PDB IDs	3FOG 3LUI 4GXB 4TKN 7RM8 9AU7
GO Terms Enriched among Interactors ?	Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Endocytosis Apolipoprotein Binding Very-low-density Lipoprotein Particle Receptor Activity Import Into Cell Clathrin-coated Pit Positive Regulation Of Lysosomal Protein Catabolic Process Cargo Receptor Activity Receptor Complex Vesicle-mediated Transport Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Receptor-mediated Endocytosis Reelin Receptor Activity Diterpenoid Metabolic Process Calcium-dependent Protein Binding Regulation Of Protein Catabolic Process Calcium Ion Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Catabolic Process Terpenoid Metabolic Process Amyloid-beta Clearance Isoprenoid Metabolic Process Astrocyte Activation Involved In Immune Response Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Early Endosome Plasma Membrane Amyloid-beta Clearance By Cellular Catabolic Process Ventral Spinal Cord Development Regulation Of Neurogenesis Artery Morphogenesis Clathrin Heavy Chain Binding Reelin-mediated Signaling Pathway Regulation Of Nervous System Development Membrane Plasma Membrane Protein Complex Low-density Lipoprotein Particle Amyloid-beta Binding Positive Regulation Of Dendrite Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Heparan Sulfate Proteoglycan Binding Regulation Of Amyloid Fibril Formation Astrocyte Activation Neuron Projection Morphogenesis Regulation Of Low-density Lipoprotein Particle Clearance