SNX17 and LDLR

Number of citations of the paper that reports this interaction (PubMedID 12169628)
42

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		SNX17	LDLR
Description		sorting nexin 17	low density lipoprotein receptor
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex	Lysosome Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Low-density Lipoprotein Particle Endolysosome Membrane Somatodendritic Compartment Receptor Complex Apical Part Of Cell Sorting Endosome PCSK9-LDLR Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding	Amyloid-beta Binding Virus Receptor Activity Protease Binding Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Very-low-density Lipoprotein Particle Receptor Activity Clathrin Heavy Chain Binding Identical Protein Binding Molecular Adaptor Activity Lipoprotein Particle Binding
	Biological Process	Kidney Development Cardiac Septum Development Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Regulation Of Endocytosis Endocytic Recycling Aorta Development Coronary Vasculature Development	Retinoid Metabolic Process Negative Regulation Of Receptor Recycling Lipid Metabolic Process Lipid Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Long-term Memory Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Phospholipid Transport Intestinal Cholesterol Absorption Cholesterol Transport Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Symbiont Entry Into Host Cell Artery Morphogenesis Positive Regulation Of Inflammatory Response Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Artery Development Response To Caloric Restriction Negative Regulation Of Astrocyte Activation Cholesterol Import Cellular Response To Fatty Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Cholesterol Metabolic Process Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Negative Regulation Of Microglial Cell Activation Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Amyloid Fibril Formation
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance Chylomicron clearance LDL clearance Retinoid metabolism and transport
Drugs			Porfimer sodium
Diseases			Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Alcohol use disorder (total score) ( 30336701) Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Microalbuminuria ( 31511532) Non-oily fish consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Serum alkaline phosphatase levels ( 33339817) Triglyceride levels ( 34074324 32902719 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 30910378 31511532 31630189 32600054) Urinary sodium to potassium ratio ( 30910378)	Abdominal aortic aneurysm ( 27899403 24046328) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Apolipoprotein B levels ( 32203549) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Cholesterol ( 31902109) Cholesterol, total ( 20686565 24097068 26582766 19060911 25961943) Coronary artery disease ( 32469254 26343387 24262325 33020668 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Cortisol levels (saliva) ( 28843169) Disorders of lipid metabolism ( 30166351) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol ( 26582766 30275531 18193044 24097068 23726366 25961943 21347282 20864672 20686565 19060906 18193043 19060910 19060911) LDL cholesterol levels ( 32203549 26690388 30698716 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222 22286219) Lipoprotein (a) levels ( 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Low density lipoprotein cholesterol levels ( 30911093 33339817 31217584 29403010) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Metabolite levels ( 21909109 22916037 23823483) Myocardial infarction ( 33532862 26343387) Myocardial infarction (early onset) ( 19198609) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Peripheral artery disease ( 31285632) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 31217584 30911093 33339817 29403010)
Interacting Genes		16 interacting genes: ACE2 ANXA2 APP HOXC8 HRAS LDLR LRP1 LRP2 LRP8 RABAC1 RIN1 RLIM RNF128 SELP SKIL VLDLR	18 interacting genes: AP1M2 APOB APOE CD36 CREBBP DAB1 DAB2 HSPA5 LDLRAP1 LRPAP1 MAP4 MTIF3 MYLIP PCSK9 PF4 SNX17 TLE5 WEE2-AS1
Entrez ID		9784	3949
HPRD ID		05812	06091
Ensembl ID		ENSG00000115234	ENSG00000130164
Uniprot IDs		B4DDM3 B4DQ37 B4DTB8 Q15036	H0YMQ3 P01130
PDB IDs		3FOG 3LUI 4GXB 4TKN 7RM8 9AU7	1AJJ 1D2J 1F5Y 1F8Z 1HJ7 1HZ8 1I0U 1IJQ 1LDL 1LDR 1N7D 1XFE 2FCW 2KRI 2LGP 2M7P 2MG9 2W2M 2W2N 2W2O 2W2P 2W2Q 3BPS 3GCW 3GCX 3M0C 3P5B 3P5C 3SO6 4NE9 5OY9 5OYL 9BD8 9BDE 9BDT 9COO
Enriched GO Terms of Interacting Partners?		Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Endocytosis Apolipoprotein Binding Very-low-density Lipoprotein Particle Receptor Activity Import Into Cell Clathrin-coated Pit Positive Regulation Of Lysosomal Protein Catabolic Process Cargo Receptor Activity Receptor Complex Vesicle-mediated Transport Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Receptor-mediated Endocytosis Reelin Receptor Activity Diterpenoid Metabolic Process Calcium-dependent Protein Binding Regulation Of Protein Catabolic Process Calcium Ion Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Catabolic Process Terpenoid Metabolic Process Amyloid-beta Clearance Isoprenoid Metabolic Process Astrocyte Activation Involved In Immune Response Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Early Endosome Plasma Membrane Amyloid-beta Clearance By Cellular Catabolic Process Ventral Spinal Cord Development Regulation Of Neurogenesis Artery Morphogenesis Clathrin Heavy Chain Binding Reelin-mediated Signaling Pathway Regulation Of Nervous System Development Membrane Plasma Membrane Protein Complex Low-density Lipoprotein Particle Amyloid-beta Binding Positive Regulation Of Dendrite Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Heparan Sulfate Proteoglycan Binding Regulation Of Amyloid Fibril Formation Astrocyte Activation Neuron Projection Morphogenesis Regulation Of Low-density Lipoprotein Particle Clearance	Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Clearance Regulation Of Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Sterol Homeostasis Cholesterol Homeostasis Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Cellular Component Organization Low-density Lipoprotein Particle Clearance Positive Regulation Of Endocytosis Cholesterol Transport Lipid Homeostasis Negative Regulation Of Lipoprotein Particle Clearance Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Clathrin Adaptor Activity Negative Regulation Of Cell Projection Organization Regulation Of Low-density Lipoprotein Particle Clearance Chylomicron Remnant Cerebellum Structural Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation Sterol Transport Amyloid-beta Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Steroid Metabolic Process Regulation Of Steroid Metabolic Process Lipoprotein Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cellular Component Organization Negative Regulation Of Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Cellular Response To Lipoprotein Particle Stimulus Alcohol Metabolic Process Receptor Ligand Activity Intermediate-density Lipoprotein Particle Positive Regulation Of Steroid Metabolic Process Regulation Of Lipid Transport Intracellular Membrane-bounded Organelle Lipoprotein Biosynthetic Process Early Endosome Regulation Of Cholesterol Metabolic Process Heparin Binding Cellular Response To Amyloid-beta Organic Hydroxy Compound Transport Positive Regulation Of Cholesterol Storage Positive Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Binding Positive Regulation Of Amyloid-beta Clearance
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?