HSP90B1 and APOB

Number of citations of the paper that reports this interaction (PubMedID 12397072)
0

Data Source:
HPRD (in vitro, in vivo)

		HSP90B1	APOB
Description		heat shock protein 90 beta family member 1	apolipoprotein B
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Sarcoplasmic Reticulum Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Sperm Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Endocytic Vesicle Lumen
	Molecular Function	Nucleotide Binding RNA Binding Protein Phosphatase Inhibitor Activity Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipase Binding Receptor Ligand Activity Low-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Response To Hypoxia Protein Folding Protein Transport Positive Regulation Of Wnt Signaling Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Apoptotic Process Sequestering Of Calcium Ion Cellular Response To Manganese Ion Cellular Response To ATP Protein Localization To Plasma Membrane	In Utero Embryonic Development Lipid Metabolic Process Triglyceride Mobilization Lipid Transport Signal Transduction Spermatogenesis Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Fertilization Response To Virus Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Lipid Catabolic Process Triglyceride Catabolic Process Cholesterol Transport Flagellated Sperm Motility Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Establishment Of Localization In Cell Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta
Pathways		Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation	Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance LDL clearance LDL clearance LDL remodeling VLDL clearance VLDL clearance Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs		Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper	Zinc chloride Zinc sulfate, unspecified form
Diseases			Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586) Binge eating behaviour and bipolar disorder ( 24882193) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 30510157) Cholesterol, total ( 19060911 20686565 24097068 25961943 26582766) Coronary artery disease ( 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Erectile dysfunction and prostate cancer treatment ( 20932654) Gastroesophageal reflux disease ( 31527586) HDL cholesterol ( 19060911 20686565 20864672 25961943 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18193043 18193044 18262040 19060906 19060910 19060911 20686565 20864672 21059979 21347282 23726366 24097068 24507774 25961943 26582766 26780889 30275531) LDL cholesterol levels ( 17463246 26690388 28334899 30698716 31087446 32203549 32759990) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipid or lipoprotein levels ( 23696881) Lipoprotein (a) levels ( 33730874) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 31589552) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Non-HDL cholesterol levels ( 32902719) Oxidized LDL cholesterol levels ( 31150472) Pancreatic cancer ( 30206226) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Red cell distribution width ( 32888494) Response to statin therapy ( 20339536) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 26690388 28334899 30275531 30718733 31087446 32902719 33339817) Triglyceride levels ( 29403010 32154731 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 18193044 19060906 19060911 20686565 20864672 25961943 26160806)
Interacting Genes		40 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CSNK2A1 CSNK2A2 CYSLTR2 EGFR ERBB2 ESR1 FANCC GPR37 GRIK1 HSPA13 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MTTP NKX3-1 NR5A2 OGT POLR2E PTEN PTPN11 PVT1 RNF10 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A	25 interacting genes: AKT2 APOA1 ARFGAP1 BGN CALR CANX CD36 HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MDM2 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3 TREM2
Entrez ID		7184	338
HPRD ID		01860	00133
Ensembl ID		ENSG00000166598	ENSG00000084674
Uniprot IDs		P14625 V9HWP2	A0AAG2UUW0 P04114 Q59HB3 Q7Z7Q0
PDB IDs		4NH9 7ULL	9BD1 9BD8 9BDE 9BDT 9COO 9E9R 9EA7 9EAG
Enriched GO Terms of Interacting Partners?		Receptor Complex Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Developmental Process Negative Regulation Of Proteolysis Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Heart Development Detection Of Molecule Of Bacterial Origin Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Lipoprotein Transport Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Catabolic Process Regulation Of Interferon-beta Production Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Cellular Response To Actinomycin D Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Negative Regulation Of Cell Differentiation Regulation Of Signal Transduction Response To Actinomycin D Detection Of Bacterial Lipoprotein Regulation Of Proteolysis ERBB Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding	Unfolded Protein Binding Protein Folding Intracellular Protein Localization Endoplasmic Reticulum Lumen Lipoprotein Particle Binding Protein Folding Chaperone Establishment Of Protein Localization Protein Transport Regulation Of Protein Stability ATP-dependent Protein Folding Chaperone Protein Folding In Endoplasmic Reticulum Low-density Lipoprotein Particle Receptor Activity Catabolic Process Melanosome Protein Catabolic Process Low-density Lipoprotein Particle Binding Endocytic Vesicle Lumen Response To Endoplasmic Reticulum Stress Protein Stabilization Amyloid-beta Metabolic Process Endoplasmic Reticulum Amyloid-beta Clearance Cholesterol Import Plasma Lipoprotein Particle Clearance Protein Refolding Macromolecule Catabolic Process Sterol Transport Amyloid-beta Clearance By Cellular Catabolic Process Post-translational Protein Targeting To Membrane, Translocation Ubiquitin Protein Ligase Binding ERAD Pathway Cellular Response To Lipoprotein Particle Stimulus High-density Lipoprotein Particle Binding Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Brush Border Membrane Regulation Of Defense Response Protein Metabolic Process Response To Hormone Apolipoprotein Binding Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Heat Shock Protein Binding Cell Surface Regulation Of Programmed Cell Death Cholesterol Transport Negative Regulation Of Programmed Cell Death
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