HSP90B1 and CSNK2A2

Number of citations of the paper that reports this interaction (PMID 11557039)
1

Data Source:
HPRD (in vitro)

		HSP90B1	CSNK2A2
Gene Name		heat shock protein 90kDa beta (Grp94), member 1	casein kinase 2, alpha prime polypeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Extracellular Matrix Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Endocytic Vesicle Lumen	Nucleus Cytosol PcG Protein Complex
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding
	Biological Process	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Actin Rod Assembly Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Cellular Protein Metabolic Process Innate Immune Response Sequestering Of Calcium Ion Cellular Response To ATP	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Axon Guidance Wnt Signaling Pathway Mitotic Spindle Checkpoint
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Scavenging by Class A Receptors ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR) Innate Immune System	Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes
Drugs		Rifabutin 2-Chlorodideoxyadenosine 1-Methoxy-2-(2-Methoxyethoxy)Ethane Adenosine-5\'-Diphosphate N-Ethyl-5\'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS		Coronary heart disease ( 21626137)
Protein-Protein Interactions		21 interactors: APOB ASGR1 BIRC2 CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 POLR2E TG TLR1 TLR2 TLR4 TXNDC11	92 interactors: ABCA1 ACACA ADH1A AQP4 ARR3 ARRB2 ASL ATF1 ATF2 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERH FGF1 FGF2 FKBP3 FOS GTF2A1 GTF2A1L HDAC1 HDAC2 HDAC6 HIST1H1C HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 JUN KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL P4HB PAK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3
Entrez ID		7184	1459
HPRD ID		01860	00279
Ensembl ID		ENSG00000166598	ENSG00000070770
Uniprot IDs		B4DHT9 P14625	P19784
PDB IDs			3E3B 3OFM 3U87
Enriched GO Terms of Interacting Partners?		Cellular Response To Stimulus Response To External Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Detection Of Molecule Of Bacterial Origin Response To Stimulus Innate Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Lipoprotein Transport Cellular Response To Triacyl Bacterial Lipopeptide Detection Of Triacyl Bacterial Lipopeptide Negative Regulation Of Mitotic Cell Cycle Cellular Response To Lipid Detection Of Biotic Stimulus Macrophage Activation Response To Abiotic Stimulus Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Immune Response Cell Communication Response To Stress Positive Regulation Of Nitric Oxide Biosynthetic Process Activation Of Innate Immune Response Cellular Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Transport Defense Response Cellular Protein Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Detection Of Bacterial Lipoprotein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Regulation Of Establishment Of Protein Localization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Mitotic Cell Cycle Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Abiotic Stimulus Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Stimulus Regulation Of Gene Expression Developmental Process Innate Immune Response Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune System Process Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Tissue Development Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus Immune Response-regulating Signaling Pathway Cellular Response To Stress Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Response To Organic Cyclic Compound Regulation Of Signaling Transcription, DNA-templated Regulation Of Phosphorus Metabolic Process Gene Expression Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Immune Response Regulation Of Phosphorylation Cell Differentiation Negative Regulation Of Signal Transduction Anatomical Structure Development Nitrogen Compound Metabolic Process Multicellular Organismal Development Defense Response Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression
Tagcloud ?		adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Difference) ?		adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Intersection) ?