HSP90B1 and MTTP

Number of citations of the paper that reports this interaction (PubMedID 9694898)
0

Data Source:
HPRD (in vivo)

		HSP90B1	MTTP
Description		heat shock protein 90 beta family member 1	microsomal triglyceride transfer protein
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Sarcoplasmic Reticulum Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Sperm Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Cytosol Basolateral Plasma Membrane Brush Border Membrane Microvillus Membrane Vesicle Receptor Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Phosphatase Inhibitor Activity Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Lipid Transporter Activity Protein Binding Phospholipid Transporter Activity Lipid Binding Apolipoprotein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Phospholipid Transfer Activity Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity Triglyceride Transfer Activity Ceramide 1-phosphate Transfer Activity Phosphatidylethanolamine Transfer Activity
	Biological Process	Response To Hypoxia Protein Folding Protein Transport Positive Regulation Of Wnt Signaling Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Apoptotic Process Sequestering Of Calcium Ion Cellular Response To Manganese Ion Cellular Response To ATP Protein Localization To Plasma Membrane	Lipid Metabolic Process Triglyceride Metabolic Process Lipid Transport Circadian Rhythm Protein Secretion Phospholipid Transport Sterol Transport Triglyceride Transport Low-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Assembly Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Cholesterol Homeostasis Lipoprotein Transport Response To Calcium Ion Establishment Of Localization In Cell Intermembrane Lipid Transfer Ceramide 1-phosphate Transport
Pathways		Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation	VLDL assembly Chylomicron assembly LDL remodeling
Drugs		Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper	Hesperetin Implitapide SLx-4090 Lomitapide
Diseases			Abetalipoproteinemia; Bassen-Kornzweig Disease
GWAS		Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Celiac disease ( 23936387) HDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Percent liver fat ( 34128465) Regular attendance at a pub or social club ( 29970889) Triglyceride levels ( 32203549)
Interacting Genes		40 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CSNK2A1 CSNK2A2 CYSLTR2 EGFR ERBB2 ESR1 FANCC GPR37 GRIK1 HSPA13 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MTTP NKX3-1 NR5A2 OGT POLR2E PTEN PTPN11 PVT1 RNF10 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A	2 interacting genes: APOB HSP90B1
Entrez ID		7184	4547
HPRD ID		01860	01144
Ensembl ID		ENSG00000166598	ENSG00000138823
Uniprot IDs		P14625 V9HWP2	B7Z7X3 E9PBP6 P55157
PDB IDs		4NH9 7ULL	8EOJ
Enriched GO Terms of Interacting Partners?		Receptor Complex Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Developmental Process Negative Regulation Of Proteolysis Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Heart Development Detection Of Molecule Of Bacterial Origin Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Lipoprotein Transport Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Catabolic Process Regulation Of Interferon-beta Production Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Cellular Response To Actinomycin D Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Negative Regulation Of Cell Differentiation Regulation Of Signal Transduction Response To Actinomycin D Detection Of Bacterial Lipoprotein Regulation Of Proteolysis ERBB Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding	Endocytic Vesicle Lumen Smooth Endoplasmic Reticulum Low-density Lipoprotein Particle Receptor Binding Mature Chylomicron Response To Virus Triglyceride Mobilization Positive Regulation Of Cholesterol Storage Very-low-density Lipoprotein Particle Assembly Lipoprotein Biosynthetic Process Extracellular Exosome Lipoprotein Catabolic Process Chylomicron Remnant Intermediate-density Lipoprotein Particle Lipase Binding Endoplasmic Reticulum Lumen Sequestering Of Calcium Ion Actin Rod Assembly Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Toll-like Receptor Signaling Pathway Sperm Plasma Membrane Protein Folding In Endoplasmic Reticulum Cellular Response To Manganese Ion Interleukin-23-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Interleukin-12 Receptor Complex Positive Regulation Of Natural Killer Cell Proliferation Extrinsic Component Of Plasma Membrane Positive Regulation Of NK T Cell Proliferation Interleukin-12-mediated Signaling Pathway Interleukin-23 Receptor Complex Type III Interferon-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Lipoprotein Transport Low-density Lipoprotein Particle Remodeling Chylomicron Low-density Lipoprotein Particle Low-density Lipoprotein Particle Clearance Retrograde Protein Transport, ER To Cytosol Cellular Response To ATP Response To Manganese Ion Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Natural Killer Cell Proliferation Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Triglyceride Catabolic Process Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Macrophage Derived Foam Cell Differentiation Very-low-density Lipoprotein Particle
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