ARL3 and UNC119

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		ARL3	UNC119
Gene Name		ADP-ribosylation factor-like 3	unc-119 homolog (C. elegans)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Golgi Apparatus Centrosome Spindle Microtubule Cytoplasmic Microtubule Midbody Photoreceptor Connecting Cilium Extracellular Vesicular Exosome Primary Cilium	Spindle Pole Centrosome Cytosol Intercellular Bridge Spindle Midzone
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding Metal Ion Binding	Protein Binding Lipid Binding
	Biological Process	Cytokinesis Kidney Development Post-Golgi Vesicle-mediated Transport Organelle Organization Smoothened Signaling Pathway Small GTPase Mediated Signal Transduction Protein Transport Intraciliary Transport Photoreceptor Cell Development Cilium Morphogenesis	Endocytosis Cytokinesis, Completion Of Separation Synaptic Transmission Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Trafficking of myristoylated proteins to the cilium Assembly of the primary cilium
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		10 interactors: ARL2BP GOLGA4 LRIF1 PDE6D RP2 TLE1 TP53 TUBA1A UBR1 UNC119	92 interactors: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A LAMA4 LCK LIG4 LUC7L2 LYN MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PPA1 PPAP2C PSMD11 PSMD2 PTPRS QTRT1 RAP1B RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TP53BP2 TP53I3 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZAK ZFP64 ZNF24
Entrez ID		403	9094
HPRD ID		05260	04927
Ensembl ID		ENSG00000138175	ENSG00000109103
Uniprot IDs		P36405	Q13432
PDB IDs			3GQQ 3RBQ 4GOJ 4GOK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Peptidyl-tyrosine Phosphorylation Visual Perception Sensory Perception Of Light Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Clathrin-mediated Endocytosis Regulation Of Cellular Amino Acid Metabolic Process Protein Localization Post-Golgi Vesicle-mediated Transport Negative Regulation Of Macromitophagy Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Oligodendrocyte Apoptotic Process Regulation Of Cellular Ketone Metabolic Process Protein Localization To Organelle Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Notch Signaling Pathway Regulation Of Catalytic Activity Cellular Localization Protein Transport Protein Localization To Nucleus Establishment Of Protein Localization Mitotic Cell Cycle Process Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Intracellular Transport Mitochondrial DNA Repair Response To Leucine Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Protein Phosphorylation Mitotic Cell Cycle Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Mitotic Cytokinetic Process Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Sensory Perception Regulation Of Intracellular Signal Transduction ER Overload Response Positive Regulation Of Phosphorylation Negative Regulation Of Macroautophagy Stress-induced Premature Senescence	T Cell Costimulation Regulation Of Catalytic Activity Response To Stress Developmental Process Immune System Process Regulation Of Defense Response To Virus By Virus System Development Anatomical Structure Development Positive Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Stimulus Immune Response Regulation Of Apoptotic Process Defense Response Cell Cycle Nervous System Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell Cycle Innate Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Leukocyte Differentiation T Cell Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Viral Process Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Cell Activation
Tagcloud ?		accord brucei congolense conservation cruzi donovani eukaryotes flanking genesis leishmania monophyly multigene organization parasites phylogeny primitive protozoan rab1 reconstitution representatives s12 salivarian transporter trypanosoma trypanosomatids trypanosomes unicellular vivax ypt6
Tagcloud (Difference) ?		accord brucei congolense conservation cruzi donovani eukaryotes flanking genesis leishmania monophyly multigene organization parasites phylogeny primitive protozoan rab1 reconstitution representatives s12 salivarian transporter trypanosoma trypanosomatids trypanosomes unicellular vivax ypt6
Tagcloud (Intersection) ?