ARL3 and RP2

Number of citations: 0 (PubMedID 16472755)
Data Source: BioGRID (pull down, pull down), HPRD (in vitro, in vivo)

		ARL3	RP2
Name		ARF like GTPase 3	RP2 activator of ARL3 GTPase
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Cytoskeleton Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Membrane Midbody Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Extracellular Exosome	Nucleoplasm Cytoplasm Golgi Apparatus Centriole Cytosol Plasma Membrane Cilium Membrane Nuclear Body Cytoplasmic Vesicle Ciliary Basal Body Cell Projection Extracellular Exosome Periciliary Membrane Compartment
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding GTPase Activator Activity Protein Binding GTP Binding Unfolded Protein Binding
	Biological Process	Mitotic Cytokinesis Kidney Development Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Smoothened Signaling Pathway Small GTPase-mediated Signal Transduction Protein Transport Intraciliary Transport Photoreceptor Cell Development Cell Division Cilium Assembly Protein Localization To Cilium Protein Localization To Ciliary Membrane	Protein Folding Post-Golgi Vesicle-mediated Transport Post-chaperonin Tubulin Folding Pathway Visual Perception Protein Transport Cilium Assembly
Pathways		Trafficking of myristoylated proteins to the cilium	Trafficking of myristoylated proteins to the cilium
Drugs		2-(N-morpholino)ethanesulfonic acid Guanosine-5'-Diphosphate	None
Diseases		None	Retinitis pigmentosa (RP)
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Blood protein levels ( 30072576 ) Brain morphology (MOSTest) ( 32665545 ) Diastolic blood pressure ( 30487518 ) Hip circumference adjusted for BMI ( 34021172 ) Mean arterial pressure ( 30487518 ) Mean arterial pressure (long-term average) ( 28348047 ) Prostate cancer ( 23535732 ) Pulse pressure ( 30487518 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 28991256 27922604 ) Systolic blood pressure ( 30487518 ) Systolic blood pressure (long-term average) ( 28348047 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: PTEN	None recorded
Interacting Genes		12 interacting genes: ARL2BP GOLGA4 LRIF1 PDE6D RP2 TBL1X TLE1 TMEM132D TP53 TUBA1A UBR1 UNC119	2 interacting genes: ARL3 PM20D2
Entrez ID		403	6102
HPRD ID		05260	02424
Ensembl ID		ENSG00000138175	ENSG00000102218
Uniprot IDs		P36405	A0A1B2JLU2 O75695
PDB IDs		Not available	2BX6 3BH6 3BH7
GO Terms Enriched among Interactors		Nervous System Process Forebrain Morphogenesis Circadian Behavior Rhythmic Behavior Dentate Gyrus Development Cilium Sensory Perception Visual Perception System Process Sensory Perception Of Light Stimulus Regulation Of Cellular Senescence Regulation Of Phosphorus Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Protein Stabilization Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Transport	Folic Acid Catabolic Process Para-aminobenzoyl-glutamate Hydrolase Activity Protein Localization To Ciliary Membrane Folic Acid Metabolic Process Dipeptidase Activity Dicarboxylic Acid Catabolic Process Pteridine-containing Compound Metabolic Process Vitamin Metabolic Process Modified Amino Acid Catabolic Process Folic Acid-containing Compound Metabolic Process Carboxypeptidase Activity Photoreceptor Cell Development Spindle Microtubule Photoreceptor Connecting Cilium Intraciliary Transport Cytoplasmic Microtubule Protein Localization To Cilium Golgi To Plasma Membrane Transport Mitotic Cytokinesis GDP Binding