LMNB1 and TP53BP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LMNB1	TP53BP2
Description		lamin B1	tumor protein p53 binding protein 2
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nuclear Lamina Nucleoplasm Intermediate Filament Membrane Nuclear Matrix Nuclear Membrane Nuclear Periphery	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Double-stranded DNA Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipase Binding Structural Constituent Of Nuclear Lamina Sequence-specific Double-stranded DNA Binding	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding
	Biological Process	Nuclear Envelope Organization Cytoskeleton Organization Nuclear Migration Heterochromatin Formation Nuclear Pore Localization Protein Localization To Nuclear Envelope	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerization of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RHOD GTPase cycle RHOF GTPase cycle	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)
Interacting Genes		42 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA5 KPNA6 LBR LMNA M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ	119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575
Entrez ID		4001	7159
HPRD ID		01036	11803
Ensembl ID		ENSG00000113368	ENSG00000143514
Uniprot IDs		B4DZT3 P20700	Q13625
PDB IDs		2KPW 3JT0 3TYY 3UMN 5BNW 5VVX 7DTG	1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cell Death Apoptotic Process Programmed Cell Death Nuclear Membrane Organization Protein Kinase C Signaling Cellular Response To Nitrogen Starvation Intracellular Signal Transduction Mitotic Nuclear Membrane Disassembly Membrane Organization Cytoplasm Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Phosphatidylethanolamine Binding Nuclear Membrane Disassembly Nuclear Inner Membrane Histone H3T6 Kinase Activity Autophagosome Maturation Membrane Disassembly Lamin Binding Nucleoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Nuclear Envelope Response To Stress Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Oxidative Stress Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Cellular Response To Staurosporine SUMO Ligase Complex Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Process Response To Reactive Oxygen Species Positive Regulation Of Programmed Cell Death Nucleus Organization Response To Hydrogen Peroxide Protein Maturation Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Import Into Nucleus Regulation Of Endodeoxyribonuclease Activity Cardiac Muscle Cell Development Cellular Response To Oxidative Stress Cardiac Cell Development Protein Phosphorylation Protein Serine Kinase Activity	Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression
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