LMNB1 and URB2

Number of citations of the paper that reports this interaction (PMID 15265697)
2

Data Source:
HPRD (in vitro)

		LMNB1	URB2
Gene Name		lamin B1	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Membrane	Nucleus Nucleolus Aggresome
	Molecular Function	Structural Molecule Activity Phospholipase Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Pathways		Apoptotic cleavage of cellular proteins DNA Damage/Telomere Stress Induced Senescence Mitotic Prophase Apoptotic execution phase Cellular Senescence Meiotic synapsis Depolymerisation of the Nuclear Lamina Nuclear Envelope Breakdown Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase M Phase Cell Cycle, Mitotic Formation of Senescence-Associated Heterochromatin Foci (SAHF) Programmed Cell Death Breakdown of the nuclear lamina Nuclear Envelope Reassembly Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Parkinson's disease (motor and cognition) ( 22658654)	Circulating myeloperoxidase levels (plasma) ( 23620142)
Protein-Protein Interactions		23 interactors: ABCG8 ATF4 CASP3 CASP6 CDK1 GIT2 GZMA GZMB LBR LMNA MBIP MELK PLEC PRKCA PRKCB PRKCD PRPH SERPINA3 SUMO4 TMPO TOR1AIP1 URB2 YWHAQ	2 interactors: LMNA LMNB1
Entrez ID		4001	9816
HPRD ID		01036	17178
Ensembl ID		ENSG00000113368	ENSG00000135763
Uniprot IDs		B4DZT3 P20700	Q14146
PDB IDs		2KPW 3JT0 3TYY 3UMN
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Envelope Organization Execution Phase Of Apoptosis Apoptotic Signaling Pathway Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Nucleus Organization Peptidyl-threonine Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Histone H3-T6 Phosphorylation Positive Regulation Of Cell Death Cellular Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Histone Phosphorylation Peptidyl-amino Acid Modification Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Response To Oxidative Stress Positive Regulation Of Catalytic Activity Endomembrane System Organization Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of MAP Kinase Activity Regulation Of Mitochondrion Organization Regulation Of Platelet Aggregation Membrane Organization Negative Regulation Of Glucose Transport Regulation Of Phosphorylation Regulation Of MAP Kinase Activity	Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Sterol Regulatory Element Binding Protein Import Into Nucleus Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Positive Regulation Of Cell Aging Mitotic Nuclear Envelope Reassembly Nuclear Envelope Reassembly SREBP Signaling Pathway Response To Sterol Depletion Negative Regulation Of Release Of Cytochrome C From Mitochondria Ventricular Cardiac Muscle Cell Development Apoptotic Process Programmed Cell Death Cell Death Death Ventricular Cardiac Muscle Cell Differentiation Negative Regulation Of Mitochondrion Organization Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Nuclear Envelope Organization Cardiac Muscle Cell Development Endoplasmic Reticulum Unfolded Protein Response Regulation Of Mitochondrion Organization Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels ER-nucleus Signaling Pathway Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Cardiac Muscle Cell Differentiation Protein Import Into Nucleus Nucleus Organization Nuclear Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Unfolded Protein Cardiocyte Differentiation
Tagcloud ?		cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Difference) ?		cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Intersection) ?