LMNB1 and MBIP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LMNB1	MBIP
Description		lamin B1	MAP3K12 binding inhibitory protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nuclear Lamina Nucleoplasm Intermediate Filament Membrane Nuclear Matrix Nuclear Membrane Nuclear Periphery	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Mitotic Spindle ATAC Complex
	Molecular Function	Double-stranded DNA Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipase Binding Structural Constituent Of Nuclear Lamina Sequence-specific Double-stranded DNA Binding	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Nuclear Envelope Organization Cytoskeleton Organization Nuclear Migration Heterochromatin Formation Nuclear Pore Localization Protein Localization To Nuclear Envelope	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Regulation Of Embryonic Development Positive Regulation Of JNK Cascade Regulation Of Cell Division Regulation Of Cell Cycle
Pathways		Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerization of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RHOD GTPase cycle RHOF GTPase cycle	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)	Hypertension ( 31513605) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335 32769997)
Interacting Genes		42 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA5 KPNA6 LBR LMNA M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ	47 interacting genes: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR1 FXR2 ING5 KAT14 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 SHANK3 SMARCB1 STX11 TGIF2LY TRIM55 TRIM63 TSC1 TXLNA TXLNB VPS28 VTA1 WDR5
Entrez ID		4001	51562
HPRD ID		01036	14368
Ensembl ID		ENSG00000113368	ENSG00000151332
Uniprot IDs		B4DZT3 P20700	B2RCV0 Q9NS73
PDB IDs		2KPW 3JT0 3TYY 3UMN 5BNW 5VVX 7DTG
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Cell Death Apoptotic Process Programmed Cell Death Nuclear Membrane Organization Protein Kinase C Signaling Cellular Response To Nitrogen Starvation Intracellular Signal Transduction Mitotic Nuclear Membrane Disassembly Membrane Organization Cytoplasm Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Phosphatidylethanolamine Binding Nuclear Membrane Disassembly Nuclear Inner Membrane Histone H3T6 Kinase Activity Autophagosome Maturation Membrane Disassembly Lamin Binding Nucleoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Nuclear Envelope Response To Stress Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Oxidative Stress Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Cellular Response To Staurosporine SUMO Ligase Complex Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Process Response To Reactive Oxygen Species Positive Regulation Of Programmed Cell Death Nucleus Organization Response To Hydrogen Peroxide Protein Maturation Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Import Into Nucleus Regulation Of Endodeoxyribonuclease Activity Cardiac Muscle Cell Development Cellular Response To Oxidative Stress Cardiac Cell Development Protein Phosphorylation Protein Serine Kinase Activity	Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Pore Localization Endosome Organization Positive Regulation Of GTPase Activity Cytoplasm Organelle Organization Positive Regulation Of Hydrolase Activity
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