ABCA1 and ERP44

Data Source: HiPPIP (Novel)

		ABCA1	ERP44
Name		ATP binding cassette subfamily A member 1	endoplasmic reticulum protein 44
Structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Endocytic Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Intracellular Vesicle	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cell Surface Specific Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Signaling Receptor Binding Protein Binding ATP Binding Phospholipid Transporter Activity High-density Lipoprotein Particle Binding Protein Transmembrane Transporter Activity Cholesterol Binding ATP Hydrolysis Activity Syntaxin Binding Phosphatidylcholine Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase-coupled Transmembrane Transporter Activity Sphingolipid Floppase Activity ATPase Binding Phosphatidylcholine Floppase Activity Phosphatidylserine Floppase Activity Cholesterol Transfer Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	Peptide Secretion Lipid Metabolic Process Phagocytosis, Engulfment Lysosome Organization G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Steroid Metabolic Process Cholesterol Metabolic Process Protein Secretion Response To Xenobiotic Stimulus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Organic Hydroxy Compound Transport Phospholipid Transport Endosomal Transport Signal Release Cholesterol Transport Response To Nutrient Levels Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Response To Vitamin B3 Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Phospholipid Translocation Establishment Of Localization In Cell Transmembrane Transport Phospholipid Homeostasis Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cytokine Stimulus Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Xenobiotic Stimulus Protein Transmembrane Transport Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Export Across Plasma Membrane	Protein Folding Response To Unfolded Protein Glycoprotein Metabolic Process Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis
Pathways		PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Neutrophil degranulation
Drugs		ATP Glyburide Probucol	None
Diseases		Tangier disease Hypoalphalipoproteinemia	None
GWAS		A body shape index ( 34021172 ) Advanced age-related macular degeneration ( 26691988 ) Allergic rhinitis ( 25085501 ) Aluminium levels ( 26025379 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Cardiometabolic and hematological traits ( 27668658 ) Cholesterol, total ( 20686565 24097068 25961943 26582766 ) Coronary artery disease ( 29212778 33020668 ) Glaucoma ( 30054594 31959993 ) Glaucoma (high intraocular pressure) ( 25173107 ) Glaucoma (multi-trait analysis) ( 31959993 ) Glaucoma (primary open-angle) ( 25173105 29452408 29891935 33627673 ) Gout ( 22179738 ) HDL cholesterol ( 18193043 18193044 19060906 19060911 20686565 20864672 21347282 21909109 23505323 24097068 25961943 26160806 26582766 26780889 28270201 30275531 ) HDL cholesterol levels ( 26690388 28334899 30698716 31087446 31694877 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) High density lipoprotein cholesterol levels ( 29403010 29615537 30718733 33339817 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) HOMA-B (corrected for HOMA-IR) ( 30369944 ) Intraocular pressure ( 25173106 28073927 29235454 29617998 29785010 30054594 30591961 31798171 31959993 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Lipid metabolism phenotypes ( 22286219 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Low high density lipoprotein cholesterol levels ( 26879886 ) Lung cancer in ever smokers ( 28604730 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolic syndrome ( 22399527 30382898 31589552 ) Metabolite levels ( 22916037 31628463 ) Myopia (pathological) ( 23049088 ) Pelvic organ prolapse ( 26545240 ) Periodontitis (Mean PAL) ( 24024966 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Systemic mastocytosis ( 32752121 ) Total cholesterol levels ( 28334899 29403010 30275531 31087446 33339817 ) Triglyceride levels ( 32154731 32203549 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 30275531 ) Type 2 diabetes ( 32499647 ) Urate levels ( 31578528 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500 ) Whole-brain volume (Alzheimer's disease interaction) ( 21116278 )	Preeclampsia ( 23551011 )
Novel Interactors		2 novel interactors: ERP44 INVS	9 novel interactors: ABCA1 CYLC2 MRPL50 NIPSNAP3A PLPPR1 PPP3R2 SMC2 STX17 TEX10
Interacting Genes		41 interacting genes: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBIN FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ PALS2 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2	3 interacting genes: ERO1A ERO1B ITPR1
Entrez ID		19	23071
HPRD ID		02501	10290
Ensembl ID		ENSG00000165029	ENSG00000023318
Uniprot IDs		B2RUU2 B7XCW9 O95477	A0A384MEE7 Q9BS26
PDB IDs		5XJY 7ROQ 7TBW 7TBY 7TBZ 7TC0 7TDT	2R2J 5GU6 5GU7 5HQP 5XWM
GO Terms Enriched among Interactors		Anchoring Junction MPP7-DLG1-LIN7 Complex Synapse Plasma Membrane Neuromuscular Junction PDZ Domain Binding Regulation Of Synaptic Assembly At Neuromuscular Junction Neurotransmitter Secretion Postsynaptic Density Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Dystrophin-associated Glycoprotein Complex Cell-cell Junction Intracellular Protein Localization Bicellular Tight Junction Protein Kinase CK2 Complex L27 Domain Binding Protein-containing Complex Organization Basolateral Plasma Membrane Cellular Component Assembly Protein-containing Complex Assembly Establishment Or Maintenance Of Cell Polarity Signal Release Protein Localization To Cell Junction Ionotropic Glutamate Receptor Binding Synaptic Vesicle Transport Adherens Junction Neurotransmitter Transport Regulation Of Macroautophagy Establishment Of Vesicle Localization Neuron Projection Vesicle Localization Membrane High-density Lipoprotein Particle Assembly Postsynaptic Membrane Regulation Of Autophagy High-density Lipoprotein Particle Binding Cytoplasm Protein Localization To Synapse Postsynaptic Density Glutamatergic Synapse Regulation Of Monoatomic Anion Transport Small GTPase-mediated Signal Transduction Regulation Of Cell Junction Assembly Rho Protein Signal Transduction Muscle Alpha-actinin Binding Apical Protein Localization Regulation Of Cellular Component Organization Regulation Of Growth Cytoskeletal Protein Binding	Calcineurin Complex Thiol Oxidase Activity Protein Folding In Endoplasmic Reticulum Protein-disulfide Reductase Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis FAD Binding Endoplasmic Reticulum Membrane Sphingolipid Floppase Activity Release Of Sequestered Calcium Ion Into Cytosol Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Negative Regulation Of Sequestering Of Calcium Ion Response To Vitamin B3 Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Cytoskeletal Calyx Endoplasmic Reticulum-Golgi Intermediate Compartment Organization