LGALS8 and ITGA4

Number of citations of the paper that reports this interaction (PMID 10852818)
26

Data Source:
HPRD (in vivo, in vitro)

		LGALS8	ITGA4
Gene Name		lectin, galactoside-binding, soluble, 8	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane Extracellular Vesicular Exosome	Plasma Membrane Cell-cell Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha4-beta7 Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Carbohydrate Binding	Fibronectin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Plasma Cell Differentiation T Cell Costimulation	Blood Vessel Remodeling Cell-matrix Adhesion Involved In Ameboidal Cell Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Blood Coagulation B Cell Differentiation Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Face Development Chorio-allantoic Fusion T Cell Migration Negative Regulation Of Protein Homodimerization Activity
Pathways			Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System
Drugs			Natalizumab Tinzaparin
Diseases
GWAS			Celiac disease ( 20190752) Monocyte count ( 23314186) White blood cell count ( 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		9 interactors: APEH BARD1 CALCOCO2 ITGA3 ITGA4 ITGB1 MID2 TAX1BP1 TRIM23	16 interactors: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN
Entrez ID		3964	3676
HPRD ID		09356	01894
Ensembl ID		ENSG00000116977	ENSG00000115232
Uniprot IDs		O00214	P13612
PDB IDs		2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4FQZ 4GXL 4HAN	3V4P 3V4V 4HKC
Enriched GO Terms of Interacting Partners?		Integrin-mediated Signaling Pathway Leukocyte Tethering Or Rolling Formation Of Primary Germ Layer Negative Regulation Of Rho Protein Signal Transduction Cell-matrix Adhesion Heterotypic Cell-cell Adhesion Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Immune System Process Response To Stress Positive Regulation Of Protein Localization To Plasma Membrane Gastrulation Cell-substrate Adhesion Cellular Extravasation Mesodermal Cell Differentiation Leukocyte Migration Response To Gonadotropin Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Maternal Process Involved In Female Pregnancy Blood Coagulation Hemostasis Mesoderm Formation Mesoderm Morphogenesis B Cell Differentiation Heart Development Negative Regulation Of MRNA 3'-end Processing Cell-matrix Adhesion Involved In Ameboidal Cell Migration Positive Regulation Of Cell-substrate Adhesion Viral Process Defense Response Protein Ubiquitination Regulation Of Body Fluid Levels Regulation Of Collagen Catabolic Process Negative Regulation Of Cell Projection Organization Wound Healing Response To Stimulus Protein Modification By Small Protein Conjugation Mesoderm Development Embryonic Morphogenesis Negative Regulation Of Protein Homodimerization Activity Calcium-independent Cell-matrix Adhesion B Cell Activation Regulation Of Locomotion Regulation Of Establishment Of Protein Localization Formation Of Radial Glial Scaffolds Response To Wounding	Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Leukocyte Tethering Or Rolling Cell-substrate Adhesion Leukocyte Migration Heterotypic Cell-cell Adhesion Regulation Of Immune System Process Integrin-mediated Signaling Pathway Cellular Extravasation Formation Of Primary Germ Layer Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Viral Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Entry Into Host Cell Positive Regulation Of Protein Metabolic Process Gastrulation Locomotion Cell Junction Assembly Cell Differentiation Cell Migration Cell Motility Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Mesoderm Formation Activation Of Protein Kinase Activity Mesoderm Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Interaction With Host Tissue Development Activation Of Protein Kinase A Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Mesoderm Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Blood Coagulation Hemostasis Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Cardiovascular System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Anatomical Structure Development ERBB Signaling Pathway Renal Water Homeostasis
Tagcloud ?		antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm libraries otud6b pdhx probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238
Tagcloud (Difference) ?		antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm libraries otud6b pdhx probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238
Tagcloud (Intersection) ?