LGALS8 and ITGA3

Number of citations: 0 (PubMedID 10852818)
Data Source: HPRD (in vitro, in vivo)

		LGALS8	ITGA3
Name		galectin 8	integrin subunit alpha 3
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Membrane Cytoplasmic Vesicle	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Growth Cone Filopodium Membrane Neuromuscular Junction Integrin Alpha3-beta1 Complex Cell Projection Receptor Complex Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Excitatory Synapse Extracellular Exosome Anchoring Junction Cell Periphery Synaptic Membrane Glutamatergic Synapse Growth Cone Filopodium
	Molecular Function	Integrin Binding Protein Binding Carbohydrate Binding	Fibronectin Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Protein Domain Specific Binding Signaling Receptor Activity Laminin Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Plasma Cell Differentiation Autophagy T Cell Costimulation Cellular Response To Virus Xenophagy Lymphatic Endothelial Cell Migration	Neuron Migration System Process Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Rho Protein Signal Transduction Heart Development Memory Response To Xenobiotic Stimulus Regulation Of Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Cell Differentiation Lung Development Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Projection Organization Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Skin Development Mesodermal Cell Differentiation System Development Leukocyte Migration Maternal Process Involved In Female Pregnancy Nephron Development Dendritic Spine Maintenance Renal Filtration Cell-cell Adhesion Postsynapse Organization Synaptic Membrane Adhesion Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		None	Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions MET activates PTK2 signaling
GWAS		Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 )	No GWAS studies recorded
Interacting Genes		22 interacting genes: ANXA1 APEH BARD1 CALCOCO2 ERBB2 G3BP1 ITGA3 ITGA4 ITGB1 LRRK2 MEFV MID2 NACC1 NR1D2 NUFIP2 TRIM17 TRIM22 TRIM23 TRIM49 TRIM5 TRIM6 WBP2	16 interacting genes: ADAM9 BIN1 CALR CD151 CD82 CD9 FHL2 FN1 HPS5 HSPD1 ITGB1 LGALS8 LINC00632 RABIF TIMP2 TSPAN4
Entrez ID		3964	3675
HPRD ID		09356	05431
Ensembl ID		ENSG00000116977	ENSG00000005884
Uniprot IDs		O00214	A0A140VJM0 P26006
PDB IDs		2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8CM8 8HL9 9FYJ	Not available
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Innate Immune Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Autophagy Immune Response Positive Regulation Of Metabolic Process Defense Response Regulation Of Metabolic Process Response To Other Organism Integrin Alpha3-beta1 Complex Response To External Biotic Stimulus Integrin Alpha4-beta1 Complex Metal Ion Binding Positive Regulation Of Catabolic Process Integrin Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Response To Stress Regulation Of Autophagy Fibronectin Binding Protein Ubiquitination Zinc Ion Binding Regulation Of Protein Localization C-X3-C Chemokine Binding Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Defense Response To Virus Cell-cell Adhesion Mediated By Integrin Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Coreceptor Activity Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Negative Regulation Of Vasoconstriction Response To Virus Neuromuscular Junction Mesodermal Cell Differentiation Protein-macromolecule Adaptor Activity Focal Adhesion Transferase Activity Regulation Of Rho Protein Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Immune System Process	Integrin Binding Focal Adhesion Protease Binding Calcium-independent Cell-matrix Adhesion Cell Surface Cell Activation Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Endothelial Cell Migration Protein-folding Chaperone Binding Positive Regulation Of Cell Migration Cell Migration Leukocyte Activation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Motility Laminin Binding Protein Maturation Extracellular Space Regulation Of Cell Motility Regulation Of Locomotion External Side Of Plasma Membrane Cell Motility Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Fusion Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Cellular Response To Low-density Lipoprotein Particle Stimulus Cell-substrate Adhesion Response To Muscle Activity Positive Regulation Of Endocytosis Cardiac Muscle Cell Differentiation Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Biological Process Involved In Interaction With Symbiont Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Cell Differentiation Cellular Component Assembly Regulation Of Neuron Differentiation B Cell Activation Positive Regulation Of Transport Lymphocyte Activation Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cardiocyte Differentiation Cell Adhesion