LGALS8 and ITGA3

Number of citations of the paper that reports this interaction (PMID 10852818)
26

Data Source:
HPRD (in vivo, in vitro)

		LGALS8	ITGA3
Gene Name		lectin, galactoside-binding, soluble, 8	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane Extracellular Vesicular Exosome	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Growth Cone Filopodium Membrane Integrin Alpha3-beta1 Complex Receptor Complex Perinuclear Region Of Cytoplasm Excitatory Synapse Extracellular Vesicular Exosome Invadopodium Membrane Cell Periphery Synaptic Membrane
	Molecular Function	Protein Binding Carbohydrate Binding	Glycoprotein Binding Fibronectin Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Protein Domain Specific Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Plasma Cell Differentiation T Cell Costimulation	Neuron Migration Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Blood Coagulation Memory Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Projection Organization Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Response To Drug Skin Development Mesodermal Cell Differentiation Leukocyte Migration Maternal Process Involved In Female Pregnancy Nephron Development Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Dendritic Spine Maintenance Renal Filtration
Pathways			Laminin interactions Integrin cell surface interactions Basigin interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APEH BARD1 CALCOCO2 ITGA3 ITGA4 ITGB1 MID2 TAX1BP1 TRIM23	15 interactors: ADAM9 BIN1 CALR CD151 CD82 CD9 FHL2 FN1 HPS5 HSPD1 ITGB1 LGALS8 RABIF TIMP2 TSPAN4
Entrez ID		3964	3675
HPRD ID		09356	05431
Ensembl ID		ENSG00000116977	ENSG00000005884
Uniprot IDs		O00214	P26006
PDB IDs		2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4FQZ 4GXL 4HAN
Enriched GO Terms of Interacting Partners?		Integrin-mediated Signaling Pathway Leukocyte Tethering Or Rolling Formation Of Primary Germ Layer Negative Regulation Of Rho Protein Signal Transduction Cell-matrix Adhesion Heterotypic Cell-cell Adhesion Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Immune System Process Response To Stress Positive Regulation Of Protein Localization To Plasma Membrane Gastrulation Cell-substrate Adhesion Cellular Extravasation Mesodermal Cell Differentiation Leukocyte Migration Response To Gonadotropin Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Maternal Process Involved In Female Pregnancy Blood Coagulation Hemostasis Mesoderm Formation Mesoderm Morphogenesis B Cell Differentiation Heart Development Negative Regulation Of MRNA 3'-end Processing Cell-matrix Adhesion Involved In Ameboidal Cell Migration Positive Regulation Of Cell-substrate Adhesion Viral Process Defense Response Protein Ubiquitination Regulation Of Body Fluid Levels Regulation Of Collagen Catabolic Process Negative Regulation Of Cell Projection Organization Wound Healing Response To Stimulus Protein Modification By Small Protein Conjugation Mesoderm Development Embryonic Morphogenesis Negative Regulation Of Protein Homodimerization Activity Calcium-independent Cell-matrix Adhesion B Cell Activation Regulation Of Locomotion Regulation Of Establishment Of Protein Localization Formation Of Radial Glial Scaffolds Response To Wounding	Cell Activation Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Calcium-independent Cell-matrix Adhesion Cellular Component Assembly Cell Junction Assembly Leukocyte Activation Positive Regulation Of Cell Development Cell-cell Adhesion Mediated By Integrin Regulation Of Neuron Differentiation Positive Regulation Of Catalytic Activity System Development Regulation Of Cell Adhesion Extracellular Matrix Disassembly Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Metabolic Process Cell Adhesion Mediated By Integrin Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Cell Adhesion Regulation Of Neurogenesis Multicellular Organismal Development Cardiocyte Differentiation Anatomical Structure Development Lymphocyte Activation Positive Regulation Of Neurogenesis Blood Coagulation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Hemostasis Immune System Process B Cell Activation Cell-matrix Adhesion Response To Hormone Regulation Of Endocytosis Cardiac Muscle Tissue Development Muscle Structure Development Developmental Process Regulation Of Catalytic Activity Single Organismal Cell-cell Adhesion Neurogenesis Cell-substrate Adhesion Positive Regulation Of Hydrolase Activity Protein Maturation Striated Muscle Cell Differentiation Regulation Of Body Fluid Levels Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm libraries otud6b pdhx probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238
Tagcloud (Difference) ?		antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm libraries otud6b pdhx probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238
Tagcloud (Intersection) ?