LGALS8 and TRIM22

Number of citations of the paper that reports this interaction (PubMedID 27693506)
53

Data Source:
BioGRID (pull down)

		LGALS8	TRIM22
Description		galectin 8	tripartite motif containing 22
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Membrane Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	Integrin Binding Protein Binding Carbohydrate Binding	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Plasma Cell Differentiation Autophagy T Cell Costimulation Cellular Response To Virus Xenophagy Lymphatic Endothelial Cell Migration	Positive Regulation Of Defense Response To Virus By Host Regulation Of DNA-templated Transcription Immune Response Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Antiviral Innate Immune Response
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Coronary artery disease ( 29212778) Malaria ( 31844061)
Interacting Genes		22 interacting genes: ANXA1 APEH BARD1 CALCOCO2 ERBB2 G3BP1 ITGA3 ITGA4 ITGB1 LRRK2 MEFV MID2 NACC1 NR1D2 NUFIP2 TRIM17 TRIM22 TRIM23 TRIM49 TRIM5 TRIM6 WBP2	13 interacting genes: CASK CIC CREB1 LGALS3 LGALS8 MFHAS1 PLEKHF2 RAF1 RERE TAF7 UBE2D1 USP7 ZZZ3
Entrez ID		3964	10346
HPRD ID		09356	05951
Ensembl ID		ENSG00000116977	ENSG00000132274
Uniprot IDs		O00214	B4DQS5 Q8IYM9
PDB IDs		2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8CM8 8HL9 9FYJ
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Innate Immune Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Autophagy Immune Response Positive Regulation Of Metabolic Process Defense Response Regulation Of Metabolic Process Response To Other Organism Integrin Alpha3-beta1 Complex Response To External Biotic Stimulus Integrin Alpha4-beta1 Complex Metal Ion Binding Positive Regulation Of Catabolic Process Integrin Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Response To Stress Regulation Of Autophagy Fibronectin Binding Protein Ubiquitination Zinc Ion Binding Regulation Of Protein Localization C-X3-C Chemokine Binding Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Defense Response To Virus Cell-cell Adhesion Mediated By Integrin Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Coreceptor Activity Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Negative Regulation Of Vasoconstriction Response To Virus Neuromuscular Junction Mesodermal Cell Differentiation Protein-macromolecule Adaptor Activity Focal Adhesion Transferase Activity Regulation Of Rho Protein Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Immune System Process	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Histone Acetyltransferase Binding Positive Regulation Of Calcium Ion Import Cerebellar Purkinje Cell Layer Maturation Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Radial Glia Guided Migration Of Purkinje Cell Response To Dehydroepiandrosterone Positive Regulation Of Cardiac Muscle Tissue Development ATF4-CREB1 Transcription Factor Complex Hormone Transport Regulation Of DNA-templated Transcription Initiation Intracellular Signal Transduction Positive Regulation Of Transforming Growth Factor Beta3 Production Hormone Secretion Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Response To Hypobaric Hypoxia MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II MRNA Transcription Chemotaxis To Arachidonate Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of NK T Cell Activation Negative Regulation Of Signal Transduction Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Calcium Ion Transport Lymphatic Endothelial Cell Migration Death-inducing Signaling Complex Assembly Negative Regulation Of MHC Class I Biosynthetic Process TFIIH-class Transcription Factor Complex Binding Spermine Transport P-TEFb Complex Binding Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling
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