LGALS8 and TRIM6

Number of citations of the paper that reports this interaction (PubMedID 27693506)
53

Data Source:
BioGRID (pull down)

		LGALS8	TRIM6
Description		galectin 8	tripartite motif containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Membrane Cytoplasmic Vesicle	Nucleus Cytoplasm Cytosol
	Molecular Function	Integrin Binding Protein Binding Carbohydrate Binding	Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity DNA-binding Transcription Factor Binding Protein Tyrosine Kinase Binding
	Biological Process	Plasma Cell Differentiation Autophagy T Cell Costimulation Cellular Response To Virus Xenophagy Lymphatic Endothelial Cell Migration	Protein Polyubiquitination Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Response To Lipopolysaccharide Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of DNA-templated Transcription Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Cellular Response To Virus Antiviral Innate Immune Response Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Stem Cell Differentiation
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Malaria ( 31844061)
Interacting Genes		22 interacting genes: ANXA1 APEH BARD1 CALCOCO2 ERBB2 G3BP1 ITGA3 ITGA4 ITGB1 LRRK2 MEFV MID2 NACC1 NR1D2 NUFIP2 TRIM17 TRIM22 TRIM23 TRIM49 TRIM5 TRIM6 WBP2	6 interacting genes: LGALS3 LGALS8 MYC RIGI TRIM5 UBE2K
Entrez ID		3964	117854
HPRD ID		09356	12123
Ensembl ID		ENSG00000116977	ENSG00000121236
Uniprot IDs		O00214	Q9C030
PDB IDs		2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8CM8 8HL9 9FYJ
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Innate Immune Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Autophagy Immune Response Positive Regulation Of Metabolic Process Defense Response Regulation Of Metabolic Process Response To Other Organism Integrin Alpha3-beta1 Complex Response To External Biotic Stimulus Integrin Alpha4-beta1 Complex Metal Ion Binding Positive Regulation Of Catabolic Process Integrin Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Response To Stress Regulation Of Autophagy Fibronectin Binding Protein Ubiquitination Zinc Ion Binding Regulation Of Protein Localization C-X3-C Chemokine Binding Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Defense Response To Virus Cell-cell Adhesion Mediated By Integrin Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Coreceptor Activity Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Negative Regulation Of Vasoconstriction Response To Virus Neuromuscular Junction Mesodermal Cell Differentiation Protein-macromolecule Adaptor Activity Focal Adhesion Transferase Activity Regulation Of Rho Protein Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Immune System Process	Regulation Of Immune System Process Positive Regulation Of Immune System Process NK T Cell Activation Positive Regulation Of Innate Immune Response Ubiquitin Protein Ligase Binding Immune System Process Pattern Recognition Receptor Activity Regulation Of Immune Response Regulation Of Lymphocyte Apoptotic Process Regulation Of Innate Immune Response Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Defense Response Response To Other Organism Lymphocyte Activation Response To Virus Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Response To External Biotic Stimulus Alpha-beta T Cell Activation Disaccharide Binding Leukocyte Activation Negative Regulation Of Immunological Synapse Formation Myc-Max Complex Regulation Of Acinar Cell Proliferation Omegasome Negative Regulation Of NK T Cell Activation Innate Immune Response Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Lymphatic Endothelial Cell Migration NK T Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of B Cell Apoptotic Process Detection Of Virus Defense Response To Symbiont Defense Response To Other Organism Carbohydrate Binding Regulation Of Defense Response Catabolic Process Positive Regulation Of Dendritic Cell Differentiation Receptor Ligand Inhibitor Activity IgE Binding Plasma Cell Differentiation Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Monocyte Differentiation Regulation Of Type III Interferon Production
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