LEP and S100A6

Number of citations of the paper that reports this interaction (PubMedID 37759746)
234

Data Source:
BioGRID (pull down)

		LEP	S100A6
Description		leptin	S100 calcium binding protein A6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	DNA Binding Signaling Receptor Binding Hormone Activity Protein Binding Peptide Hormone Receptor Binding Leptin Receptor Binding	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovulation From Ovarian Follicle Response To Hypoxia Positive Regulation Of Cytokine Production Placenta Development Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Cardiac Muscle Hypertrophy Glucose Metabolic Process Regulation Of Gluconeogenesis Energy Reserve Metabolic Process Glycerol Biosynthetic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Phagocytosis Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Female Pregnancy Response To Nutrient Circadian Rhythm Cholesterol Metabolic Process Bile Acid Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Adult Feeding Behavior Fatty Acid Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Autophagy Negative Regulation Of Lipid Storage Response To Activity Regulation Of Metabolic Process Sexual Reproduction Central Nervous System Neuron Development Insulin Secretion T Cell Differentiation Regulation Of Intestinal Cholesterol Absorption Response To Nutrient Levels Positive Regulation Of TOR Signaling Negative Regulation Of Appetite Prostaglandin Secretion Response To Estradiol Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Proliferation Response To Insulin Cellular Response To Insulin Stimulus Response To Vitamin E Leptin-mediated Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Intracellular Signal Transduction Bone Mineralization Involved In Bone Maturation Aorta Development Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Import Into Nucleus Hormone Metabolic Process Glucose Homeostasis Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of MAPK Cascade Cellular Response To Leptin Stimulus Response To Ethanol Regulation Of Fat Cell Differentiation Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Negative Regulation Of D-glucose Import Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of Bone Remodeling Positive Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Lipid Biosynthetic Process Positive Regulation Of Developmental Growth Regulation Of Insulin Secretion Regulation Of Steroid Biosynthetic Process Intestinal Absorption Leukocyte Tethering Or Rolling Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Transport Elastin Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Lipoprotein Lipid Oxidation Adipose Tissue Development Negative Regulation Of Cartilage Development Negative Regulation Of Glucagon Secretion Cellular Response To L-ascorbic Acid Cellular Response To Retinoic Acid Regulation Of Brown Fat Cell Differentiation Energy Homeostasis Cell Surface Receptor Signaling Pathway Via STAT Bone Growth Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Fat Cell Apoptotic Process Activation Of Protein Kinase C Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Glutamine Transport Positive Regulation Of Hepatic Stellate Cell Activation	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation
Pathways		Signaling by Leptin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and deacylation of Ghrelin
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		BMI at 1.5 years old ( 31575865) BMI at 8 months old ( 31575865) Body size at age 10 ( 32376654) circulating leptin levels ( 26833098 32917775) circulating leptin levels adjusted for BMI ( 26833098 32917775) High density lipoprotein cholesterol levels ( 29403010) Interleukin-6 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Type 2 diabetes ( 23945395 26818947 32499647)	HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		12 interacting genes: A2M CLU CRP GHRL HK3 HSF2BP LEPR PRKAA2 S100A6 S100P SIGLEC6 UCN	50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53
Entrez ID		3952	6277
HPRD ID		01249	00237
Ensembl ID		ENSG00000174697	ENSG00000197956
Uniprot IDs		A4D0Y8 P41159	P06703
PDB IDs		1AX8 7Z3Q 8AVE 8AVF 8AVO 8K6Z 8X80 8X81 8X85	1K8U 1K96 1K9K 1K9P 2M1K 4YBH
Enriched GO Terms of Interacting Partners?		Extracellular Region Regulation Of Feeding Behavior Positive Regulation Of Corticotropin Secretion Regulation Of Corticotropin Secretion Calcium-dependent Protein Binding Regulation Of Behavior Negative Regulation Of Complement Activation Secretory Granule Lumen Regulation Of Response To Food Glucose Metabolic Process Regulation Of Complement Activation Regulation Of Appetite Low-density Lipoprotein Particle Receptor Binding Glial Cell Proliferation Hexose Metabolic Process Positive Regulation Of Behavior Monosaccharide Metabolic Process Regulation Of Response To Nutrient Levels Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Humoral Immune Response Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Leptin Receptor Activity Response To Hormone Positive Regulation Of Muscle Contraction Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Protein Localization To Lysosome Vascular Process In Circulatory System Platelet Alpha Granule Lumen Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Circulatory System Process Generation Of Precursor Metabolites And Energy Energy Homeostasis [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Negative Regulation Of Hormone Secretion G Protein-coupled Receptor Binding Histone Deacetylase Inhibitor Activity Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Feeding Behavior Interleukin-8 Binding Regulation Of Cytokine Production	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation
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