S100A6 and GH2

Number of citations of the paper that reports this interaction (PubMedID 37759746)
234

Data Source:
BioGRID (pull down)

		S100A6	GH2
Description		S100 calcium binding protein A6	growth hormone 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Endomembrane System Endosome Lumen Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding	Growth Hormone Receptor Binding Hormone Activity Growth Factor Activity
	Biological Process	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation	Response To Nutrient Levels Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Growth Hormone Receptor Signaling Pathway
Pathways			Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)	Height ( 31562340 33713608) Prudent dietary pattern ( 28644415) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53	3 interacting genes: GHR S100A6 S100P
Entrez ID		6277	2689
HPRD ID		00237	00750
Ensembl ID		ENSG00000197956	ENSG00000136487
Uniprot IDs		P06703	A0A0M6L0J9 P01242
PDB IDs		1K8U 1K96 1K9K 1K9P 2M1K 4YBH
Enriched GO Terms of Interacting Partners?		Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation	Protein Homodimerization Activity Calcium-dependent Protein Binding Growth Hormone Receptor Activity Growth Hormone Receptor Complex Response To Growth Hormone Response To Cycloheximide Regulation Of Growth Hormone Receptor Signaling Pathway Response To Gravity Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Extracellular Region Taurine Metabolic Process Identical Protein Binding Monoatomic Ion Transmembrane Transporter Activity Tropomyosin Binding S100 Protein Binding Protein Tyrosine Kinase Activator Activity Proline-rich Region Binding Cartilage Development Involved In Endochondral Bone Morphogenesis Calcium Ion Binding Transition Metal Ion Binding Growth Hormone Receptor Signaling Pathway Microvillus Membrane Response To Food Regulation Of Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT SH2 Domain Binding Peptide Hormone Binding Protein Tyrosine Kinase Binding Cytokine Binding Growth Factor Binding Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Population Proliferation Cytokine Receptor Activity Positive Regulation Of Fibroblast Proliferation
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